中国免疫学杂志2016，Vol.32Issue(9)：1346-1349,4.DOI:10.3969/j.issn.1000-484X.2016.09.022
Vδ2γδ T细胞亚群在慢性HCV感染中的特征
Characteristics of Vδ2 γδ T cells in patients with chronic hepatitis C
摘要
Abstract
Objective:To study the role of γδ T cells and Vδ1 and Vδ2 T subsets played in patients with chronic hepatitis C.Methods:The percentage of peripheral bloodγδT cells and Vδ1 and Vδ2 T subsets cells was assessed by flow cytometry ( FACS) . Results:There were no significant differences in the percentage of circulating γδ T cells and Vδ1 and Vδ2 T subsets between HCV-infected patients and healthy controls ( HCs).However,The number of peripheral blood Vδ2 T cells from HCV-infected patients was positively correlated with serum alanine aminotransferase ( ALT) levels,but showed no correlation with serum HCV RNA.Peripheral Vδ2 T cells from HCV-infected patients were in activated status.The expression of CD107a was enhanced in Vδ2 T cells from HCV-infected patients compared to HCs.Conclusion:Vδ2 T cells were involved in liver injury in chronic HCV-infected patients.关键词
丙型肝炎病毒/γδT细胞/Vδ2T细胞/病毒滴度/谷丙转氨酶Key words
HCV/γδT cell/Vδ2 T cell/Viral titer/ALT分类
医药卫生引用本文复制引用
殷文伟,张琼方,邵建营,童师雯..Vδ2γδ T细胞亚群在慢性HCV感染中的特征[J].中国免疫学杂志,2016,32(9):1346-1349,4.基金项目
本文为国家自然科学基金项目（81401664，81301423）、中国博士后科学基金资助项目、重庆市博士后科学基金资助项目（Xm2014132）和重庆市前沿与应用基础研究（一般）项目（cstc2015jcyjA10071）。 （）
