中国免疫学杂志2016，Vol.32Issue(9)：1357-1359,1363,4.DOI:10.3969/j.issn.1000-484X.2016.09.025
1350例新生儿溶血三项试验的血清学检测分析
Analysis of three serological tests results of hemolytic disease of newborn in 1 350 cases
郭莹莹 1霍姿含 1王震 2刘冰1
作者信息
- 1. 吉林大学白求恩第一医院，长春 130021
- 2. 吉林大学中日联谊医院，长春 130000
- 折叠
摘要
Abstract
Objective:To explore blood type distribution of newborns hemolytic disease ( HDN ) caused by maternal and neonatal blood type incompatibility and analyze the value of hemolysis three trials in the diagnosis of HDN.Methods:Hemolysis three trials of type O or Rh negative maternal cord blood samples and hyperbilirubinemia of the newborn blood samples from January 2014 to 2016 were detected by micro-column gel test cards.Then the results were statistically analyzed.Results:(1) There were 918 cases of maternal and neonatal blood type incompatibility in all 1350 cases.569 cases were detected HDN positive with the rate of 62%( 569/918).Among 569 cases,the positive rate of direct anti-globulin test,free antibody test and antibody released test were 27.9%(159/569),86.5%(492/569) and 100% respectively.There was statistical difference of the combination of direct anti-globulin test negative,free antibody test positive and antibody released test positive compared with other combinations ( P<0.05 ).( 2 ) There was statistical difference of HDN positive rate between ABO 73.8%(551/747) and Rh 10.5%(18/171)in 918 cases of blood type incom-patibility.(3)There was statistical difference between A positive rate of 80%(280/350) and B positive rate of 68.3%(271/397) in 747 cases of ABO incompatibility.(4)There was statistical difference among RhD positive rate of 17.7%(14/79),RhE positive rate of 6.8%(4/59) and RhC positive rate of 0(0/33).Conclusion: Antibody released test was the most sensitive test in hemolysis three trials to diagnose HDN.The probability of HDN positive caused by maternal and neonatal ABO blood type incompatibility was significantly higher than Rh.The probability of HDN positive with type A newborns was significantly higher than type B.The probability of HDN positive caused by RhD blood type incompatibility was significantly higher than RhE and RhC.关键词
新生儿溶血病/直接抗人球蛋白试验/游离抗体试验/抗体释放试验Key words
Hemolytic disease of newborns/Direct anti-globulin test/Free antibody test/Antibody released test分类
医药卫生引用本文复制引用
郭莹莹,霍姿含,王震,刘冰..1350例新生儿溶血三项试验的血清学检测分析[J].中国免疫学杂志,2016,32(9):1357-1359,1363,4.
