中国全科医学2016，Vol.19Issue(27)：3311-3316,6.DOI:10.3969/j.issn.1007-9572.2016.27.011
18F-氟脱氧葡萄糖PET/CT与鳞状细胞癌抗原在宫颈鳞癌治疗后随访中的应用价值
Value of 18 F-FDG PET/CT and SCC Antigen in the Detection of Cervical Cancer after Treatment
摘要
Abstract
Objective To assess the value of 18 F - FDG PET/ CT and serum squamous cell carcinoma(SCC)antigen in the detection of residual,recurrent or metastasis in patients with cervical squamous cancer after treatment. Methods From January 2008 to April 2014,155 patients with cervical squamous cancer suspected residual,recurrent or metastasis after treatment,which had undergone 18 F - FDG PET/ CT scans and SCC antigen measurement in Fourth Hospital of Hebei Medical University were retrospectively analyzed. Diagnostic efficiency of 18 F - FDG PET/ CT and SCC antigen were analyzed according to pathology and follow - up results. Results Of the 155 patients included in this study,128 patients were malignant,while 27 were benign. The overall patient - based sensitivity,specificity,accuracy,positive predictive value( PPV) and negative predictive value(NPV)of 18 F - FDG PET/ CT for the detection of malignancy were 99. 2% ,85. 2% ,96. 8% ,96. 9% and 95. 8% ,while SCC antigen were 80. 5% ,70. 4% ,78. 7% ,92. 8% and 43. 2% ,respectively. All the 4 false - positive 18 F - FDG PET/ CT results were associated with negative SCC antigen except one,and 1 false - negative PET/ CT results was positive SCC antigen,8 false - positive SCC antigen were associated with 7 negative on 18 F - FDG PET/ CT,while 25 false -negative SCC antigen were all positive 18 F - FDG PET/ CT results. The sensitivity,specificity,accuracy,PPV and NPV of combination index for the detection of malignancy were 100. 0% ,59. 3% ,92. 9% ,92. 1% and 100. 0% ,respectively. The area under ROC curve of 18 F - FDG PET/ CT,SCC antigen and combination index were 0. 918〔95% CI(0. 838,0. 998)〕, 0. 754〔95% CI(0. 646,0. 862)〕and 0. 796〔95% CI(0. 678,0. 914)〕. Conclusion 18 F - FDG PET/ CT imaging and Serum SCC antigen,which have important value in cervical squamous cancer,can be complementary method in cases of suspected malignant focus exist after treatment.关键词
宫颈肿瘤/断层摄影术,螺旋计算机/氟脱氧葡萄糖 F18/癌,鳞状细胞Key words
Uterine cervical neoplasms/Tomography,helical computed/Fluorodeoxyglucose F18/Carcinoma, squamous cell分类
医药卫生引用本文复制引用
张召奇,赵新明,王建方,张敬勉,王颖晨,和玲燕..18F-氟脱氧葡萄糖PET/CT与鳞状细胞癌抗原在宫颈鳞癌治疗后随访中的应用价值[J].中国全科医学,2016,19(27):3311-3316,6.基金项目
河北省医学科学研究重点课题计划（ ZD20140350）；河北省普通高等学校强势特色学科肿瘤学组课题 （）
