中国畜牧兽医2016，Vol.43Issue(9)：2379-2387,9.DOI:10.16431/j.cnki.1671-7236.2016.09.024
炎症反应致肌肉蛋白质降解机理的研究进展
Research Progress on the Mechanisms of Inflammation-induced Muscle Protein Degradation
摘要
Abstract
Skeletal muscle wasting is a consequence of the decrease of muscle protein synthesis and/or degradation acceleration,and often accompanies with various serious diseases,such as pathogen infection,injury and tumor.At present,many studies have shown that the systemic in-flammation is playing an important role in the process of muscle wasting.Based on the current lit-erature,we present an overview of the molecular and cellular mechanisms that contribute to the inflammation-induced muscle wasting,mainly including the ubiquitin-proteasome pathway (UPP ),autophagy-lysosomal pathway (ALP ),PI3K/Akt pathway,p38/MAPK pathway and NF-κB pathway,which hope to offer the guidance for the treatment of skeletal muscle wasting.关键词
骨骼肌消耗/蛋白质降解/炎症反应Key words
skeletal muscle wasting/protein degradation/inflammation分类
医药卫生引用本文复制引用
王胜军,刘妍,刘玉兰,汪文俊,张晶..炎症反应致肌肉蛋白质降解机理的研究进展[J].中国畜牧兽医,2016,43(9):2379-2387,9.基金项目
湖北省自然科学基金(2013CFA029、2015CFB514) （2013CFA029、2015CFB514）
