中国药房2016，Vol.27Issue(26)：3601-3604,4.DOI:10.6039/j.issn.1001-0408.2016.26.01
多药耐药基因多态性与利培酮及其代谢物血药浓度的相关性
The Correlation between Multidrug Resistance Gene Polymorphism and Plasma Concentration of Risperi-done and Its Metabolite
楼江 1严伟 1王刚 1徐萍 2李焕德 2王飞1
作者信息
- 1. 杭州市第一人民医院药学部，杭州 310006
- 2. 中南大学湘雅二医院临床药学研究室，长沙 410011
- 折叠
摘要
Abstract
OBJECTIVE:To discuss the correlation between multidrug resistance gene (MDR1) polymorphisms and plasma concentration of risperidone,9-hydroxyrisperidone and total active substance in Han patients with schizophrenia. METHODS:78 Han inpatients with schizophrenia in Mental Health Institute of Second Xiangya Hospital of Central South University from Dec. 2011 to Jan. 2013 were selected,LC-MS/MS was conducted to determine the plasma concentration of risperidone,9-hydroxyrisperi-done and total active substance,PCR-LDR was adopted to determine the genotyping of C1236T,G2677T and C3435T of patients, and one-way ANOVA was used to detect the correlation between C1236T,G2677T and C3435T polymorphisms and plasma concen-tration/dose calibration ratio (C/D) value of risperidone,9-hydroxyrisperidone and total active substance. RESULTS:The average plasma concentrations of risperidone,9-hydroxyrisperidone and total active substance for 78 patients were(13.58±8.31),(25.62± 15.52)and(39.24±25.76)ng/ml,respectively;the distribution frequencies of C1236T,G2677T and C3435T met the Hardy-Wein-berg equilibrium(P>0.05);the risperidone C/D value of patients with C12367T CT and TT genotype were higher than those with CC genotype,risperidone and total active substance C/D values of patients with G2677T TT genotype were higher than those with GG genotype,the differences were statistically significant (P<0.05);while there were no significant differences in analyte C/D values in other patients(P>0.05). CONCLUSIONS:The MDR1 C1236T and G2677T polymorphisms are associated with plasma concentration of risperidone and total active substance in Han patients with schizophrenia.关键词
多药耐药/基因多态性/利培酮/9-羟基利培酮/总活性物/血药浓度/剂量校正比/相关性Key words
Multidrug resistance/Gene polymorphism/Risperidone/9-hydroxyrisperidone/Total active substance/Plasma concentration/dose calibration ratio/Correlation分类
医药卫生引用本文复制引用
楼江,严伟,王刚,徐萍,李焕德,王飞..多药耐药基因多态性与利培酮及其代谢物血药浓度的相关性[J].中国药房,2016,27(26):3601-3604,4.
