中国药房2016，Vol.27Issue(26)：3630-3632,3.DOI:10.6039/j.issn.1001-0408.2016.26.09
我院136例难治性肺部感染患者支气管肺泡灌洗液病原菌分布及耐药性分析
Analysis of Pathogen Distribution and Drug Resistance in 136 Cases of Bronchoalveolar Lavage Fluid from Patients with Refractory Pulmonary Infection of Our Hospital
倪鸿昌 1严玉兰 2凌芳3
作者信息
- 1. 镇江市第一人民医院药剂科，江苏镇江 212002
- 2. 镇江市第一人民医院呼吸科，江苏镇江 212002
- 3. 江苏大学附属医院药剂科，江苏镇江 212001
- 折叠
摘要
Abstract
OBJECTIVE:To investigate the pathogen distribution and drug resistance situation in bronchoalveolar lavage fluid (BALF) from patients with refractory pulmonary infection,and provide reference for clinical rational drug use. METHODS:The sputum and BALF specimen of 136 inpatients with refractory pulmonary infection from the First People’s Hospital of Zhenjiang City from Jan. 2012 to Dec. 2015 were cultured and identified,pathogen detection was compared,and results of drug sensitivity test for pathogen in BALF specimen was analyzed. RESULTS:The positive rates of sputum and BALF specimen of 136 inpatients were 22.06%and 47.79%,with statistical significance(P<0.01);a total of 32 and 72 strains were isolated,they mainly were Ste-notrophomonas maltophilia,Pseudomonas aeruginosa,Acinetobacter baumannii and Staphylococcus aureus. S. maltophilia in BALF was sensitive to minocycline and levofloxacin;resistance rate of P. aeruginosa to common antibiotics was lower than 50%;A. baumannii was sensitive to imipenem,ampicillin sodium and sulbactam sodium,amikacin and minocycline;S. aureus was sen-sitive to linezolid,chloramphenicol and vancomycin. CONCLUSIONS:The positive rate of BALF specimen is higher than spu-tum,the pathogens are mainly Gram-negative bacteria. Clinic should rationally select antibiotics based on the drug sensitivity test and clinical symptoms.关键词
难治性肺部感染/支气管肺泡灌洗液/病原菌/耐药性Key words
Refractory pulmonary infection/Bronchoalveolar lavage fluid/Bacterial culture/Drug sensitivity test分类
医药卫生引用本文复制引用
倪鸿昌,严玉兰,凌芳..我院136例难治性肺部感染患者支气管肺泡灌洗液病原菌分布及耐药性分析[J].中国药房,2016,27(26):3630-3632,3.
