中国药房2016，Vol.27Issue(26)：3636-3639,3640,5.DOI:10.6039/j.issn.1001-0408.2016.26.11
我院患儿使用热毒宁注射液致不良反应的影响因素分析
Analysis of Influential Factors of ADR Induced by Reduning Injection in Pediatric Patients of Our Hospital
摘要
Abstract
OBJECTIVE:To observe the characteristics and influential factors of aderverse drug reactionl(ADR)induced by Re-duning injection. METHODS:The clinical information of pediatric patients receiving Reduning injection were collected from pediatric department of our hospital during Nov. 2014-Oct. 2015. Using ADR as outcome indicators,case control in the queue design was con-ducted. The influential factors of ADR induced by Reduning injection were analyzed by using binary univariate and multivariate Logis-tic regression analysis,Cox regression fitted 1∶3 matching Logistic regression analysis. RESULTS:Of 9 187 cases,the average age of children was(4.21±2.63)year-old;there were 23 ADR cases,with the incidence of 0.25%. There were 21 cases of rash(9 cas-es of combined pruritus)and 2 severe ADR cases(including 1 case of twitching limbs,blue complexion,peripheral cold,high fe-ver,leg pain and 1 case of limbs cold and high fever);23 cases of ADR symptoms finally disappeared after treated. Based on drug dose and usage of low concentrations and low drip rate in our hospital,regression analysis showed that age,sex,drug dose,solvent amount,concentration,drip rate,source of children,drug combination,the group number of daily continuous intravenous infusion, infusion order,the days of continuous medication and other factors were not statistically significant (P>0.05);the incidence of ADR induced by Reduning injection was 0.11% in the group of 1-3 years old children and was 0.31% in the group of 3-16 years old children. There was no statistical significance between 2 groups(P>0.05). CONCLUSIONS:The reasons for ADR induced by Re-duning injection might be the drug itself,the wrong methods,etc. Reasonable drug dosage,low concentration,low drip rate,using sophisticated filters infusion device and changing infusion device while dressing can reduce the occurrence of ADR.关键词
热毒宁注射液/不良反应/队列内病例对照/影响因素Key words
Reduning injection/Aderverse drug reaction/Case control in the queue/Influential factor分类
医药卫生引用本文复制引用
施长城,张鹏飞,祁天寿..我院患儿使用热毒宁注射液致不良反应的影响因素分析[J].中国药房,2016,27(26):3636-3639,3640,5.基金项目
扬州市科技指导性计划（临床药学）资助项目 （）
