中国药物评价2016，Vol.33Issue(3)：153-154,164,3.
格列卫治疗儿童Ph染色体阳性急性淋巴细胞白血病9例疗效观察
Clinical Effects of Gleevec on 9 Cases of Philadelphia Chromosome-positive Acute Lymphoblastic Leukaemia in Children
毛彦娜 1刘炜 1李彦格 1田亮 1宋丽丽1
作者信息
摘要
Abstract
Objective: To observe the clinical effect of gleevec on Ph+ acute lymphoblastic leukaemia ( Ph+ ALL ) cases in children.Methods:9 cases of children Ph+ALL were retrospectively analyzed.All of the data were obtained from department of hematol-ogy/oncology, in our hospital from January 2011 to May 2014.All the patients were treated with 340 mg/m2・d of oral gleevec in 0.5 h af-ter meals, 30d for a course of treatment meanwhile, observed the genetics remission rate and recorded the occurrence of side effects trea-ted with gleevec.Results:9 cases(100%) were achieved complete genetic remission.With median follow-up time for 18 months, 9 ca-ses of survival rate of Ph+ALL patients was 67%in 2~4 years.Of the patients, 2 cases of recurrence after 13 months gave up treat-ment.1 case was treated for allogeneic hematopoietic stem cell transplantation after recurrence.Different levels of hypocytosis occured after 16 weeks (medium time was approximately 3~4 weeks).Including animia 7 cases(78%), thrombocytopenia 5 cases(56%), leukocyto-penia 6 cases(67%), pancytopenia 3 cases(33%).Nausea and vomiting occurred in 4 cases(44%) and muscle pain occurred in 2 ca-ses(22%) which returned to normal after discontinuation or reduction.Conclusion:Gleevec is both effective and safe for the treatment of Ph+ALL.关键词
格列卫/儿童/白血病Key words
Gleevec/Children/Leukaemia分类
医药卫生引用本文复制引用
毛彦娜,刘炜,李彦格,田亮,宋丽丽..格列卫治疗儿童Ph染色体阳性急性淋巴细胞白血病9例疗效观察[J].中国药物评价,2016,33(3):153-154,164,3.
