中国中医药信息杂志2016，Vol.23Issue(10)：51-55,5.DOI:10.3969/j.issn.1005-5304.2016.10.013
复方钩藤降压片对自发性高血压大鼠血管重塑单核细胞趋化蛋白-1和基质金属蛋白酶-9表达的影响
Effects of Compound Uncaria Hypotensive Tablets on Expressions of MCP-1 and MMP-9 of Vascular Remodeling in Spontaneously Hypertensive Rats
摘要
Abstract
Objective To observe the effects of Compound Uncaria Hypotensive Tablets on expressions of MCP-1 and MMP-9 of vascular remodeling in spontaneously hypertensive rats (SHR); To discuss it possible mechanism of action. Methods Totally 24 12-week old male SHR were randomly divided into SHR model group, Compound Uncaria Hypotensive Tablets group, and positive medicine group, with 8 rats in each group. Another 8 WKY rats were set as normal control group. Medication groups were given relevant medicine for gavage for successive 6 weeks. Noninvasive tail cuff method was used to observe blood pressure; morphological changes in thoracic aorta and renal artery were observed by HE staining; immunohistochemistry was used to detect the protein expressions of MCP-1 and MMP-9 in thoracic aortic wall. Results Protein expressions of MCP-1 and MMP-9 in thoracic aortic wall of SHR model group were significantly higher than those of normal control group (P<0.01); Compared with the SHR model group, protein expressions of MCP-1 and MMP-9 in thoracic aortic wall decreased significantly in the medication groups (P<0.05, P<0.01); Compared the Compound Uncaria Hypotensive Tablets group and positive medicine group, there was no obvious difference in protein expressions of MCP-1 and MMP-9 in thoracic aortic wall. Conclusion Compound Uncaria Hypotensive Tablets can reduce the blood pressure of SHR, reduce inflammation reaction, and regulate vascular remodeling, which mechanism may be related to down-regulation of expressions of MCP-1 and MMP-9 in SHR aortic endothelial cells.关键词
复方钩藤降压片/自发性高血压大鼠/血管重塑/单核细胞趋化蛋白-1/基质金属蛋白酶-9Key words
Compound Uncaria Hypotensive Tablets/spontaneously hypertensive rats/vascular remodeling/MCP-1/MMP-9分类
医药卫生引用本文复制引用
冯进,张稳,卿俊,刘惠敏,谭元生..复方钩藤降压片对自发性高血压大鼠血管重塑单核细胞趋化蛋白-1和基质金属蛋白酶-9表达的影响[J].中国中医药信息杂志,2016,23(10):51-55,5.基金项目
国家自然科学基金（81473616）；湖南省科技厅重点项目（2013SK2025）；湖南省教育厅重点项目（15A142）；湖南省中医药管理局重点项目（201403）；湖南省中药粉体与创新药物省部共建国家重点实验室开放基金 （）
