中华神经创伤外科电子杂志2016，Vol.2Issue(5)：289-292,4.DOI:10.3877/cma.j.issn.2095-9141.2016.05.007
高压氧对脑外伤大鼠脑内兴奋性氨基酸水平的影响
Effects of hyperbaric oxygen on the level of excitatory amino acids in the brain of rats with brain injury
摘要
Abstract
Objective To study the effect of hyperbaric oxygen on the level of excitatory amino acids in the brain of rats with brain injury. Methods By making the models of traumatic brain injury in rats and design randomized experimental group: model control group, high pressure group, high concentration oxygen group and hyperbaric oxygen group were treated with brain injury rats. The contents of glutamic acid (Glu) and aspartate (Asp) were measured in rats at third days, sixth days and ninth days respectively. The contents of glutamic acid (Glu) and aspartate (Asp) were measured in rats at third days, sixth days and ninth days respectively. Results The content of Glu and ASP in the brain tissue of rats with brain injury increased significantly and hyperbaric oxygen can be significantly reduced content of Glu and ASP. Compared with model control group, there were significant differences (P<0.05). The high pressure group and high concentration oxygen group could not significantly inhibit the expression of Glu and Asp. Compared with the model group had no significant difference (P>0.05). Conclusion Hyperbaric oxygen can significantly inhibit the release of excitatory amino acids in brain tissue of rats with traumatic brain injury and reduce the secondary brain damage after traumatic brain injury,while high pressure, high concentration of oxygen can not significantly inhibit the release of EAA.关键词
脑损伤/兴奋性氨基酸/高压氧治疗Key words
Cerebral injury/Excitatory amino acids/Hyperbaric oxygen therapy引用本文复制引用
贺仕清,邹云龙,雷北平..高压氧对脑外伤大鼠脑内兴奋性氨基酸水平的影响[J].中华神经创伤外科电子杂志,2016,2(5):289-292,4.基金项目
湖南省卫生厅一般项目（B2010-056) （）
