神经药理学报2015，Vol.5Issue(5)：7-14,8.
康脑液对脑缺血再灌注大鼠神经再生相关因子的影响
Effect of Kangnaoye on Nerve Regeneration Related Factor in Rats of Cerebral Ischemia-Reperfusion Injury
摘要
Abstract
Objective:To observe the effect of Kangnaoye on nerve regeneration related factor in rats of cerebral ischemia-reperfusion injury.Methods:150healthy adult male Sprague Dawley rats were randomly divided into 5 groups;Kangnaoye high,middle and low dose group(24、12、6 g·kg-1·d-1),sham operated group and model group. Longa method was used to establish the middle cerebral artery occlusion(MACO) model. TTC staining method was used to observe infarction volume change in rats after 24 h. Collecting specimens in 1 d、3 d、7 d and 14 d,immunohistochemical method was used to observe the change of thegrowth associated protein-43(GAP-43) after cerebral ischemic and the expression of neurite outgrowth inhibitor-A(NOGO-A) protein .The nervous function deficit scores were evaluated at 2 h、1 d、3 d、7 d、14 d after reperfusion.Results:Compared with model group,the neurological functions were improved significantly in kangnaoye groups(P<0.05). Kangnaoyehigh,middle and low dose groups were significantly decreased than model group in cerebral infarction volume ratio(P<0.01). The expression levels of GAP-43 were also significantly higher in kangnaoye high and middle dosages groups than model group,at the same time the expression of NOGO-A were lower,which has significant differences(P<0.05 orP<0.01). Conclusion:Kangnaoye can promote neurotization and improve the motor skill recovery after cerebral infarction.关键词
康脑液/脑缺血再灌注/神经再生Key words
kangnaoye/cerebral ischemia-reperfusion/nerve regeneration分类
医药卫生引用本文复制引用
孙炎,宋爱霞,薛茜,邹玉安..康脑液对脑缺血再灌注大鼠神经再生相关因子的影响[J].神经药理学报,2015,5(5):7-14,8.基金项目
河北省卫生厅课题基金资助项目 （）
