神经药理学报2015，Vol.5Issue(5)：20-27,8.
大黄结肠靶向微丸在大鼠胃肠道内的分布及释放方法学研究
Study on the Distribution and Drug Releasing in Digestive Tract of Colon-Targeted Pellets ofRhubarb in Rats
摘要
Abstract
Objective:To investigate the conveying and drug release in vivoof colon target pellets ofRhubarb in rats.Methods:The rhubarb colon-targeted pellets were administered by homemade rat mouth gag. The rats were respectively killed at different time points after administering,and the gastrointestinal tracts were dissected. The appearance of pellets was observed and the sum of pellets were counted. The pellets distribution rates in the digestive tract in rats were calculated at different time point after administering. After the residue level of aloe-emodin,emodin and chrysophanol in pellets were respectively determined by HPLC,also the emodin in rats,gastrointestinal tissue and content. The accumulative releasing was calculated and the drug concentration-time curve in the gastrointestinal tract was drawn,then the drug release property was evaluated.Results:The pellets were transferred to colon completely and obvious late release effect. The colon distribution rate could reach the highest after 10~12 h,52.7%. In 8~16 h, drugs had a high concentration in the cecum and colon. Final release dosage percentage was 88.99%. Conclusion:Rhubarb colon-targeted pellets possessed the characteristic of drug release in colon.关键词
大黄结肠靶向微丸/大鼠/胃肠道/分布/药物释放Key words
rhubarb colon-targeted pellets/rat/digestive tract/distributiont/drug releasing分类
医药卫生引用本文复制引用
张丹参,梅艳飞,宋晓敏,庄忠宝,薛贵平..大黄结肠靶向微丸在大鼠胃肠道内的分布及释放方法学研究[J].神经药理学报,2015,5(5):20-27,8.基金项目
国家自然科学基金项目 （）
