神经药理学报2015，Vol.5Issue(5)：49-56,8.
电压门控性钠通道Nav1.7及其特异性阻断剂在神经病理性痛中的研究进展
Progress of Voltage Gated Sodium Channel Nav1.7 and Its Specifi c Blockers in Neuropathic Pain
摘要
Abstract
Voltage gated sodium channels(Nav) play important roles in generation and conduction of pain. In pain conduction pathway,Nav1.7 is selectively expressed in small-diameter peripheral somatic sensory neurons and sympathetic ganglion neurons. Nav1.7 modulates neuronal excitability through amplifing subthreshold of depolarizations and setting up the thresholds of Nav1.8 and Nav1.9. This review will focus on the progress of neuropathic pain caused by mutations in Nav1.7. Nav1.7 can be used as an effective target for the treatment of pain. Highly selective Nav1.7 blockers will be of great clinical value in the treatment of pain.关键词
神经病理性痛/电压门控性钠通道/Nav1.7/钠通道阻断剂/背根神经节/通道结构Key words
neuropathic pain/voltage gated sodium channel/Nav1.7/sodium channel blocker/dorsal root ganglia/channel structure分类
医药卫生引用本文复制引用
王川,单彬,王琼,张海林..电压门控性钠通道Nav1.7及其特异性阻断剂在神经病理性痛中的研究进展[J].神经药理学报,2015,5(5):49-56,8.基金项目
国家自然科学基金资助项目（No.31171097、No.31270882），国家重点基础研究发展计划（973计划）（No.2013CB531302），河北省自然科学基金资助项目（No.C2014206419），教育部留学回国人员科研启动基金项目（No.2013-693），河北省高等学校科学技术研究项目重点项目 （）
