摘要
Abstract
Objective:To analyze the sexual development status of children with β-thalassemia major.Method:43 cases of β-thalassemia major patients in our hospital from April 2014 to April 2016 were selected as the research objects.Chemical luminescence microparticle immunoassay was used for the detection of follicle stimulating hormone(FSH),estradiol(E2),progesterone(P),luteinizing hormone (LH) and testosterone(T).The ferritin(Fer) and hemoglobin(Hb) were detected.The sexual development status of regular blood transfusion group and irregular blood transfusion group,regularly removing iron group and irregularly removing iron group were compared.Result:8 cases of male children development,6 patients’ testis were bigger than 4 ml,2 patients’ testis were bigger than 6 ml,12 cases were undeveloped.Two girls were with menstruation,the uterine accessories ultrasound of 21 cases showed undeveloped,the sex hormone stimulation test suggested that gonadal axis was not started.Compared with the developed group,the Fer of the undeveloped group was higher,the Hb level was significantly lower,the differences were statistically significant(P<0.05).The number of patients with sexual development in the regular blood transfusion group and the regularly removing iron group was 10 cases(83.3%),10 cases (90.9%) respectively,the probability of sexual development was significantly higher than that of the irregular blood transfusion group and the irregularly removing iron group,the differences were statistically significant(P<0.05).Compared with the irregular blood transfusion group and the irregularly removing iron group,the Fer was lower and the Hb level was higher in the regular blood transfusion group and the regularly removing iron group,the differences were statistically significant(P<0.05).The FSH,P,E2,LH,T in the undeveloped group were lower than those in the developed group, and the differences were statistically significant(P<0.05).Fer was negatively correlated with the personality index(P<0.05),and Hb was positively correlated with each sex hormone index(P<0.05).Conclusion:β-thalassemia major children have the problem of sexual developmental delays.The sexual development of patients with hemoglobin maintained in higher level and ferritin in lower level was better.Regular blood transfusion and iron chelation therapy can reduce the iron overload and promote sexual development.β-thalassemia major children shall be paid attention to and receive regular treatment.关键词
重型β地中海贫血/性发育/铁过载Key words
β-thalassemia major/Sexual development/Iron overload分类
医药卫生
