北京中医药大学学报2016，Vol.39Issue(9)：734-738,5.DOI:10.3969/j.issn.1006-2157.2016.09.007
ERα基因 TA 重复序列多态性与月经过少中医证候相关性研究
Correlation of TA repeat polymorphisms of estrogen receptor-αgene and TCM patterns of hypomenorrhea
摘要
Abstract
Objective To find out the distribution of TA (thymine-adenine)repeat polymorphisms of estrogen receptor-α(ERα)gene in patients with unexplained hypomenorrhea as well as its correlation with TCMpatterns of hypomenorrhea.Methods The present case-control study was carried out by using the sequencing methods to find out the TA repeat polymorphisms distribution differences in patients and controls,and in TCMpatterns of patients.Results The frequency of TA19 allele in experimental group was 22.73%,significantly higher than 4.55% in control group (P =0.007).The rank of distribution of TA19 allele in patterns listed as kidney deficiency,blood stasis and blood deficiency,showed no significant difference (X2 =5.137,P =0.077 ).But the distribution of TA19 in pattern of kidney deficiency and blood deficiency showed significant difference (X2 =4.574,P =0.032,OR =0.283). Conclusion The correlation of TA repeat polymorphisms of estrogen receptor-αgene and TCM patterns of unexplained hypomenorrhea was proved.The TA19 allele was more susceptibility to hypomenorrhea, whose association with the different TCMpatterns showed no statistical significance.关键词
月经过少/雌激素受体a/TA重复序列/中医证候Key words
hypomenorrhea/estrogen receptor-α/TA repeat sequence/TCMpatterns分类
医药卫生引用本文复制引用
林晓华,金哲,刘京,谭展望..ERα基因 TA 重复序列多态性与月经过少中医证候相关性研究[J].北京中医药大学学报,2016,39(9):734-738,5.基金项目
国家自然科学基金青年科学基金资助项目（No．81403428），河北省中医药管理局资助项目（No．2014052），河北省科技厅自筹经费资助项目 （）
