福建畜牧兽医2016，Vol.38Issue(5)：50-52,53,4.
禽核酸疫苗的研究进展
DNA vaccination of poultry
摘要
Abstract
This review describes studies in this field performed exclusively on birds (chickens, ducks and turkeys). No evaluations of avian DNA vaccine efficacy performed on mice as preliminary tests have been taken into consideration. The review first describes the state of the art for DNA vaccination in poultry: pathogens targeted, plasmids used and different routes of vaccine administration. Sec-ond, it presents strategies designed to improve DNA vaccine efficacy:influence of the route of administration, plasmid dose and age of birds on their first inoculation; increasing plasmid uptake by host cells; addition of immunomodulators; optimization of plasmid back-bones and codon usage;association of vaccine antigens and finally, heterologous prime-boost regimens. The final part will indicate ad-ditional properties of DNA vaccines in poultry: fate of the plasmids upon inoculation, immunological considerations and the use of DNA vaccines for purposes other than preventing infectious diseases.关键词
核酸疫苗/禽类/传染病/佐剂/免疫途径Key words
DNA vaccine/Avian/nfectious diseases/Adjuvants/Routes引用本文复制引用
唐静静,周巧丽,殷光文,江和基,黄志坚..禽核酸疫苗的研究进展[J].福建畜牧兽医,2016,38(5):50-52,53,4.基金项目
国家自然科学基金（31502058）、福建省教育厅科研项目（JA15159）、大学生创新项目（201610389148）资助。 （）
