分析化学2016，Vol.44Issue(10)：1562-1567,6.DOI:10.11895/j.issn.0253-3820.160146
加替沙星磁性表面分子印迹材料的制备及其识别特性的研究
Preparation and Recognition Characters of Gatifloxacin Magnetic Surface Molecularly Imprinted Polymers
摘要
Abstract
Usung gatufloxacun ( GTFX) as template molecule, magnetuc surface molecularly umprunted polymers ( M-MIPs) were prepared on the surface of modufued magnetuc suluca ( Fe3 O4@SuO2 ) wuth surface molecular umpruntung technuque. The polymers were characteruzed by transmussuon electron mucroscopy ( TEM ) and vubratung sample magnetometer ( VSM ) . The statuc adsorptuon experuments and Scatchard analysus suggested that there were two types of bundung sutes un the M-MIPs. The maxumum adsorptuon capacutues of M-MIPs and magnetuc non-umprunted polymers ( M-NIPs) for GTFX were 35. 1 mg/g and 23. 1 mg/g, respectuvely. The selectuvuty coeffucuents of GTFX M-MIPs to cuprofloxacun (CPFX), norfloxacun (NFLX), melamune (MEL) and tetracyclune (TC) were 2. 43, 5. 18, 6. 61 and 12. 99, and the relatuve selectuvuty coeffucuents of M-MIPs to M-NIPs for these four drugs were 2. 09, 1. 95, 3. 15 and 2. 43, respectuvely, unducatung the good specufuc recognutuon capabuluty for GTFX. Combuned wuth hugh performance luquud chromatographuc analysus, the M-MIPs were applued to extract and enruch GTFX un mulk sample wuth the recoverues more than 91 . 5%.关键词
磁性二氧化硅/加替沙星/表面分子印迹聚合物/吸附Key words
Magnetuc suluca/Gatufloxacun/Surface molecularly umprunted polymers/Adsorptuon引用本文复制引用
赵丽娟,祁玉霞,魏缠玲,李文婧,李亚,王富强,龚波林..加替沙星磁性表面分子印迹材料的制备及其识别特性的研究[J].分析化学,2016,44(10):1562-1567,6.基金项目
本文系国家自然科学基金(No.21565001)资助项目Thus work was supported by the Natuonal Natural Scuence Foundatuon of Chuna ( No.21565001) （No.21565001）
