中国实用神经疾病杂志2016，Vol.19Issue(19)：1-3,3.
异丙酚对大鼠抑郁模型电休克治疗后认知功能和海马Glu浓度及Tau蛋白磷酸化程度的影响
The impact of propofol on cognitive function and Glu concentration and extent of Tau phosphorylation in de-pressed rats after electroconvulsive therapy
摘要
Abstract
Objective To discuss the impact of propofol on cognitive function ,Glu concentration and extent of Tau phos‐phorylation in depressed rats after electroconvulsive therapy .Methods Female Sprague Dawley (SD) rats were selected to es‐tablish depression model and field test was used to select 20 rats ,with scores 30 to 80 .These SD rats were divided them into four groups randomly (n=5):A group injected with saline ;B group injected with propofol ;C group treated with ECT ;D group treated with ECT and propofol ;E group selected normal rats in contrast and injected with saline .Three days after treatment , Morris water maze test was used to record escape latency (s) ,the number of passing by the original platform position ,the resi‐dence time of the original platform quadrant (s) ,then Glu concentration and extent of Tau phosphorylation were also deter‐mined by relevant experiments .Results Compared to A group ,the escape latency(s) prolonged ,the number of passing by the original platform position ,the residence time of the original platform quadrant (s) reduced ,Glu concentration and extent of Tau phosphorylation in hippocampus raised in C group (P<0.05);compared to C group ,the escape latency (s) reduced ,the number of passing by the original platform position ,the residence time of the original platform quadrant (s) raised ,Glu concentration and extent of Tau phosphorylation in hippocampus reduced in D group (P<0.05) .Conclusion ECT can promote Tau phos‐phorylation through rising Glu concentration ,and then influence cognitive function of depressed rats .Propofol can regulate Glu concentration and Tau phosphorylation that aroused by ECT ,and then improve cognitive function of depressed rats .关键词
异丙酚/电休克疗法/认知功能/谷氨酸/T au蛋白Key words
Propofol/Electroconvulsive therapy/Cognitive function/Glu/Tau分类
医药卫生引用本文复制引用
姚柱炜,蒙剑锋,栾宏权..异丙酚对大鼠抑郁模型电休克治疗后认知功能和海马Glu浓度及Tau蛋白磷酸化程度的影响[J].中国实用神经疾病杂志,2016,19(19):1-3,3.基金项目
深圳市科技计划 （）
