中国实用神经疾病杂志2016，Vol.19Issue(21)：1-2,2.
大鼠中枢神经系统中神经肽S的表达及对睡眠功能的影响
The effect of expression level of neuropeptide S in central nervous system on sleep function in rats
摘要
Abstract
Objective To investigate the relationship between the expression of neuropeptide S deprived from rats and sleep .Methods A total of 27 rats were divided into CC group(normal-control group) ,TC group(environmental-control group) and SD group(sleepful-control group) .The expression level of neuropeptide S in hypothalamus was tested and compared after raising all rats for one ,three and five days .Results Weight loss and no smooth ,wet unkempt fur happened after sleep depriva‐tion in rats .The tails and claws of some rats were worn-off ,and the rats were prone to be angry and aggressive ,all of which were more obvious on the fifth day after sleep deprivation .On the first ,third and fifth days ,no statistical differences were found between CC group and TC group as for the expression levels of neuropeptide S mRNA in hypothalamus(P>0.05) ,how‐ever the expression levels in SD group on the third and fifth days were significantly higher than those on the first day (P<0.05) and in CC group and TC group(P<0.05) .Conclusion Neuropeptide S may play a role in promoting human bodies’ a‐wakening and have a certain regulating effect on sleep and awakening ,which may be related to many diseases such as insomnia and should be further studied .关键词
睡眠剥夺/神经肽S/睡眠Key words
Sleep deprivation/Neuropeptide S/Sleep分类
医药卫生引用本文复制引用
叶建新,林航,穆军山,崔晓萍..大鼠中枢神经系统中神经肽S的表达及对睡眠功能的影响[J].中国实用神经疾病杂志,2016,19(21):1-2,2.基金项目
南京军区医学科技创新课题 （）
