摘要
Abstract
Objective To investigate the related risk factors for aspirin resistance in the secondary prevention of cerebral infarction ,in order to provide new data and reference index in the future .Methods We recruited 120 patients with cerebral in‐farction and 56 healthy controls in our study and detected platelet aggregation rate by using turbidimetry method (LPT ) and combining ADP induction and arachidonic acid induction to judge aspirin resistance .All cases were divided into aspirin-resist‐ance(AR) group ,semi-resistance(ASR) group(ASR) ,aspirin-sensitivity (AS) group and normal group based on the level of platelet aggregation .At the same time ,we recorded patients’ age ,gender ,blood sugar ,total cholesterol ,triglyceride ,low densi‐ty lipoprotein cholesterol ,diabetes mellitus and cerebral infarction history .Results Univariate analysis showed that Gender , age ,diabetes ,transient ischemic attack(TIA) ,large-artery occlusion lacunar(LAA) in the AR ,ASR and AS groups showed sta‐tistical differences compared with those in the normal group .And diabetes as well as TIA history was the independent risk fac‐tor for AR(diabetes :OR=13.297 ,95% CI 2.422 to 72.984 ,P=0.003;TIA history :OR=5.019 ,95% CI 1.026 to 24.538 ,P=0.046) .Conclusion AR may have close relations with diabetes and previous TIA history ,among which diabetes is most closely related with AR .关键词
脑梗死/二级预防/阿司匹林抵抗/危险因素/糖尿病Key words
Cerebral infarction/Secondary prevention/Aspirin resistance/Risk factors/Diabetes分类
医药卫生
