中国实用神经疾病杂志2016，Vol.19Issue(21)：8-10,3.
缺血性脑卒中患者氯吡格雷抵抗与颈动脉狭窄的相关性分析
Correlation of clopidogrel resistance and carotid artery stenosis in ischemic stroke patients
薛森新 1周伯荣 2宋成宪 1邓燕华2
作者信息
- 1. 广州医科大学附属第三医院 康复科 广州 510150
- 2. 广州医科大学附属第三医院 神经内科 广州 510150
- 折叠
摘要
Abstract
Objective To investigate the correlation between clopidogrel resistance (CR) and carotid artery stenosis in patients with ischemic stroke .Methods Turbidimetry was used to measure the changes of platelet aggregation rate after the included patients with ischemic stroke taking 75 mg of clopidogrel per day for two weeks .The patients were divided into either CR or clopidogrel sensitivity (CS) group according to the changes of platelet aggregation rate .The demographic and clinical da‐ta of both groups were compared .Multivariate logistic regression analysis was used to identify the independent risk factors for CR .Results A total of 228 patients with ischemic stroke were included ,among whom 54 cases (23.68% ) were in the CR group and 174(76.32% ) were in the CS group .Single factor analysis showed that there were statistical differences between the two groups in terms of age(P=0.015) ,platelet count(P=0.012) ,moderate carotid stenosis(P=0.034) ,gender(P=0.049) and diabetes(P=0.032) .Multiariable logistic analysis results presented that age(P=0.004) ,platelet count(P=0.025) ,diabe‐tes(P=0.026) and moderate carotid stenosis(P=0.002) were the independent risk factors for CR .Conclusion CR existing in patients with ischernic stroke may be associated with a variety of factors ,in which moderate carotid artery stenosis is one of the risk factors for CR .关键词
缺血性脑卒中/氯吡格雷抵抗/血小板聚集/颈动脉狭窄Key words
Ischemic stroke/Clopidogrel resistance/Platelet aggregation/Carotid artery stenosis分类
医药卫生引用本文复制引用
薛森新,周伯荣,宋成宪,邓燕华..缺血性脑卒中患者氯吡格雷抵抗与颈动脉狭窄的相关性分析[J].中国实用神经疾病杂志,2016,19(21):8-10,3.
