摘要
Abstract
Objective To explore the clinical efficacy of mirtazapine combined with repetitive transcranial magnetic stim‐ulation(rTMS) in elderly anxiety patients with sleep disorder .Methods Two hundred elderly cases with both anxiety and sleep disorder were divided into combination group (mirtazapine+rTMS) and control group(only mirtazapine) according to the order of admission ,each group had 100 cases .Two group received treatment for eight weeks and then clinical efficacies of two groups were compared .Results After treatment ,both the PSQI scale containing seven factors (sleep quality ,onset time ,sleep time ,sleep efficiency ,sleep disturbance ,hypnotic drug and daytime function) and PSQI scores(2.14 ± 2.39) in the combination group ,were significantly lower than those in the control group ,and all differences were statistically significant (P<0.05) .Af‐ter treatment ,the values of PSG sleep parameters(sleep latency ,REM latency ,total sleep time ,sleep efficiency ,awake times) in the combination group were significantly better than those in the control group ,with statistically significant differences (P<0.05) .Compared with control group ,the combination group held less SAS scores .Additionally ,the curative rate in the combi‐nation group(47% ) was obviously higher than that in the control group(32% ) .Conclusion The therapy of mirtazapine com‐bined with rTMS can more effectively improve clinical efficacy .关键词
米氮平/经颅重复磁刺激法/睡眠障碍/老年/焦虑症Key words
Mirtazapine/Transcranial magnetic stimulation/Sleep disorders/Elderly/Anxiety分类
医药卫生
