中国实用神经疾病杂志2016，Vol.19Issue(21)：19-21,3.
血清VEGF水平与外伤性脑梗死患者预后的相关性分析
The correlation between serum VEGF level and prognosis in traumatic cerebral infarction patients treated by decompressive craniotomy
谭燕萍 1张继平 2梁慧超3
作者信息
- 1. 广东佛山市禅城区朝阳医院药剂科佛山 528000
- 2. 广东佛山市第二人民医院科教科佛山 528000
- 3. 广东佛山市第一人民医院脑科康复医院药剂科佛山 528000
- 折叠
摘要
Abstract
Objective To investigate the correlation between serum VEGF level and prognosis in traumatic cerebral in‐farction patients treated by decompressive craniotomy .Methods We selected 25 patients with severe brain injury complicated with cerebral infarction from 2011 January to 2014 as study group and at the same time we selected 50 healthy volunteers as control group .Patients in study group were treated with decompressive craniotomy and then we observed the clinical efficacy . And VEGF levels in two groups before and after treatment were compared .Results The VEGF levels before and after treat‐ment in the study group were significantly higher than that in the control group ,and the study group showed higher level after treatment .During the follow-up period ,the higher VEGF level the patients got ,the less GOS scores ,the more NIHSS scores and the severer neurological functional deficit the patients had ,with statistically significant differences (P<0.05) .Pearson cor‐relation analysis showed that VEGF level after treatment had positive correlations with the severity of neurological functional deficit and the level of GOS scores(correlation coefficient r=0.65 ,r=0.71 ;P<0.05) .Conclusion The level of serum VEGF in patients with traumatic cerebral infarction may be increased significantly ,and the higher level indicates poor prognosis ,which suggests that VEGF level can be used as indicator to evaluate disease condition ,treatment effect and prognosis .关键词
颅脑损伤/外伤性脑梗死/去骨瓣减压术/血管内皮生长因子/预后Key words
Craniocerebral injury/Traumatic cerebral infarction/Decompressive craniotomy/Vascular endothelial grow th factor/Prognosis分类
医药卫生引用本文复制引用
谭燕萍,张继平,梁慧超..血清VEGF水平与外伤性脑梗死患者预后的相关性分析[J].中国实用神经疾病杂志,2016,19(21):19-21,3.
