中国临床保健杂志2016，Vol.19Issue(5)：552-554,3.DOI:10.3969/J.issn.1672-6790.2016.05.031
乳腺癌HER-2靶向治疗的现状与发展前景
Current situation and prospect of HER2 targeted therapy in breast cancer
摘要
Abstract
Objective Human epidermal growth factor receptor 2(HER2)plays a central role in the family of the epidermal growth factor receptor(EGFR or ErhB),this article aims at the present situation and problems of HER2 targeted therapy.Methods The search for relevant articles of HER2 targeted therapy were undertaken in the PubMed, CNKI,Wanfang data and VIP,and total of 52 articles were included.Results HER2 signalling can regulate cell prolif-eration,survival and differentiation,which is closely related to the development of breast cancer,stomach cancer,lung cancer,ovarian cancer and other tumors.HER2 targeted therapies can help to improve the clinical efficacy of chemother-apy drugs and to improve patients disease-free survival and 5-year survival rate,but the drug resistance of cancer be-comes more and more serious,which has been aroused a cause for concern.Conclusion HER2 targeted therapy plays an important role in improving treatment effect of breast cancer.Its drug resistance needs to be further studied,and a more effective treatment is expected to be developed.关键词
乳腺肿瘤/受体,表皮生长因子/分子靶向治疗Key words
Breast neoplasms/Receptor,epidermal growth factor/Molecular targeted therapy分类
医药卫生引用本文复制引用
龚欢秀,沈国栋,胡世莲,邱卫华..乳腺癌HER-2靶向治疗的现状与发展前景[J].中国临床保健杂志,2016,19(5):552-554,3.基金项目
安徽省自然科学基金面上项目（1408085MH167）；安徽省科技攻关项目 （）
