日用化学工业2016，Vol.46Issue(9)：514-518,5.DOI:10.13218/j.cnki.csdc.2016.09.006
神经酰胺ⅢB 纳米脂质体的制备及功效评价
Preparation and efficacy evaluation of ceramide ⅢB nanoliposome
摘要
Abstract
Ceramide ⅢB nanoliposome was prepared by high pressure homogenization technique. Properties of the product were measured as particle size,71. 7 nm;PDI,0. 214;Zeta potential,- 23. 3 mV;rate of drug loading,2. 3%;rate of encapsulation,95. 9% . The in vitro skin permeation and retention tests were performed with Franz diffusion cell method. Results showed that the cumulative permeation and skin retention in 24 h was 709. 23 and 75. 07 μg / cm2 ,respectively. The skin retention of ceramide ⅢB nanoliposome cream product in 24 h was 6 times higher than that of conventional ceramide ⅢB cream product with the same mass fraction. The experiment was continued for 40 d on mouse skin and the results demonstrated that ceramide ⅢB nanoliposome exhibits a significant epidermal hydration capacity and total ceramides mass concentration as comparing with that of the control test group.关键词
化妆品添加剂/神经酰胺ⅢB/纳米脂质体/功效评价Key words
additives of cosmetics/ceramide ⅢB/nanoliposome/efficacy evaluation分类
化学化工引用本文复制引用
李霞,田仁德,许琦,郭凤凤,刘卫..神经酰胺ⅢB 纳米脂质体的制备及功效评价[J].日用化学工业,2016,46(9):514-518,5.基金项目
国家自然科学基金面上项目 （）
