上海针灸杂志2016，Vol.35Issue(10)：1143-1146,4.DOI:10.13460/j.issn.1005-0957.2016.10.1143
基于细胞凋亡探讨针刺作用机理的研究述评
Research Review of the Action Mechanism of Acupuncture Based on Cell Apoptosis
摘要
Abstract
Apoptosis refers to the programmed death process of cells modulated by genes. It plays an important role in promoting the evolution of organisms, regulating the development of multiple systems, and maintaining the stability of internal environment. The major apoptosis pathways include mitochondrial pathways, death receptor pathways, and endoplasmic reticulum pathways. With the rapid development of the scientific research on acupuncture, it’s revealed that cell apoptosis should be closely related to the action of acupuncture. So far, the major apoptosis factors involved in relevant researches are P53, Bcl-2 family, Cyt-C, Caspase, Fas/Fasl, TNFR1/TNF-, and FADD-Caspase8, and PERK, etc. Via influencing these apoptosis factors or genes, acupuncture can produce various effects in improving tissue ischemia, protecting neural cells, reducing inflammation, and correcting endocrine disorders. This article summarized and reviewed the apoptosis pathways and key factors related to the action of acupuncture, to provide some beneficial references for future studies.关键词
针刺/细胞凋亡/作用机理/综述文献Key words
Acupuncture/Cell apoptosis/Action mechanism/Literature review分类
医药卫生引用本文复制引用
陈琳,吴巧凤,杨明晓,邓淑芳,柏琳,陈亮,梁繁荣..基于细胞凋亡探讨针刺作用机理的研究述评[J].上海针灸杂志,2016,35(10):1143-1146,4.基金项目
国家重点基础研究发展计划(2012CB518501) （2012CB518501）
教育部霍英东基础研究基金(141041) （141041）
四川省科技厅项目(2015JQO058) （2015JQO058）
