信阳师范学院学报（自然科学版）2016，Vol.29Issue(4)：524-527,4.DOI:10.3969/j.issn.1003-0972.2016.04.009
Cu2+、Fe3+、Zn2+对香豆素-3-羧酸与牛血清白蛋白相互作用的影响
Effect of Cu(Ⅱ),Fe(Ⅲ),Zn(Ⅱ)on the Interaction Between Bovine Serum Albumin and Coumarin-3-carboxylic Acid
摘要
Abstract
The effect of Cu2+ ,Fe3 + ,Zn2+ on the interaction between bovine serum albumin (BSA)and cou-marin-3-carboxylic acid was investigated by fluorescence spectroscopy.The results showed that three metal ions have effect on the quenching and combination of coumarin-3-carboxylic acid on BSA,and both the quenching constants and binding constants increased.The hydrophobic effect played an important role in the binding process of two compounds and the type did not changed in the presence of Zn2+ .The driving force changed to e-lectrostatic interaction in the presence of Cu2+ and Fe3 + .It indicated that Cu2+ ,Fe3 + and Zn2+ had important in-fluence on the interaction between coumarin-3-carboxylic acid and BSA.关键词
金属离子/香豆素-3-羧酸/牛血清白蛋白/荧光光谱Key words
metal ions/coumarin-3-carboxylic acid/BSA/fluorescence spectroscopy分类
化学化工引用本文复制引用
郁有祝,王艳飞,郭玉华..Cu2+、Fe3+、Zn2+对香豆素-3-羧酸与牛血清白蛋白相互作用的影响[J].信阳师范学院学报（自然科学版）,2016,29(4):524-527,4.基金项目
国家自然科学基金项目(21302003) （21302003）
安阳市科技计划项目 （）
安阳工学院院科研基金项目(YJJ2015008) （YJJ2015008）
