中国康复理论与实践2016，Vol.22Issue(10)：1190-1195,6.DOI:10.3969/j.issn.1006-9771.2016.10.017
基于线栓法大鼠大脑中动脉闭塞的局灶性脑缺血模型的比较研究
Comparative Study of Focal Cerebral Ischemia Model Based on Middle Cerebral Artery Occlusion with Su-ture-occluded Method in Rats (review)
缪培 1张通 2米海霞1
作者信息
- 1. 首都医科大学康复医学院，北京市100068
- 2. 中国康复研究中心北京博爱医院，北京市100068
- 折叠
摘要
Abstract
There are many ways to prepare middle cerebral artery occlusion (MCAO) rat model. The focal cerebral ischemia model es-tablished by the suture-occluded method is widely accepted as an ideal focal cerebral ischemia model, which can be used in the basic and clinical study of cerebral vascular diseases. However, it still has the defects of high technical requirement, large model difference and high animal mortality. A variety of focal cerebral ischemia models were established by changing the retention time of the thread, the road the thread plugging into, the type of thread bolt and the depth of the thread plugging. This article compared different suture-occluded method, as well as the suture-occluded method to other modeling methods, different cerebral ischemia models may be different in the pathophysiology of cerebral infarction, and the effects may also be different.关键词
线栓法/局灶性脑缺血模型/大脑中动脉闭塞/综述Key words
suture-occluded method/focal cerebral ischemia model/middle cerebral artery occlusion/review分类
医药卫生引用本文复制引用
缪培,张通,米海霞..基于线栓法大鼠大脑中动脉闭塞的局灶性脑缺血模型的比较研究[J].中国康复理论与实践,2016,22(10):1190-1195,6.
