中华肝脏外科手术学电子杂志2016，Vol.5Issue(5)：319-322,4.DOI:10.3877/cma.j.issn.2095-3232.2016.05.012
鲍曼不动杆菌感染和耐药性分析
Analysis on infection and drug resistance of Acinetobacter baumannii
摘要
Abstract
ObjectiveTo investigate the infection and drug resistance ofAcinetobacter baumannii in the Third Afifliated Hospital of Sun Yat-sen University.MethodsClinical data of 209 patients infected withAcinetobacter baumanniiin the Third Affiliated Hospital of Sun Yat-sen University between June 2012 and December 2014 were retrospectively analyzed. Among the patients, 160 were males and 49 were females with the average age of (55±18) years old. The informed consents of all patients were obtained and the local ethical committee approval was received. The specimen source, ward distribution and drug resistance of Acinetobacter baumannii were observed. The comparison of drug resistance was conducted using Chi-square test and Bonferroni test.ResultsTwo hundred and thirty-six strains ofAcinetobacter baumannii were isolated in the hospital, and most were isolated from Department of Liver Transplantation (50 strains, 21.2%), the next were Department of Rehabilitation (34 strains, 14.4%) and Surgical Intensive Care Unit (SICU) (21 strains, 8.9%). Sputum specimens were the main source ofAcinetobacter baumannii, respectively accouting for 84%, 76% and 71% in the three wards, whereAcinetobacter baumannii had high drug resistance to the common antibiotics used in clinical. The drug resistance rate to sulfamethoxazole ofAcinetobacter baumannii in Department of Liver Transplantation was 76%, signiifcantly higher than 33% of SICU (χ2=11.60,P<0.017).ConclusionsAcinetobacter baumannii is found most in Department of Liver Transplantation, which is followed by Department of Rehabilitation and SICU. Sputum specimen is the main source ofAcinetobacter baumannii.Acinetobacter baumannii detected in the three wards has a high drug resistance to common antibiotics.关键词
鲍氏不动杆菌/感染/多药耐药相关蛋白质类/肝移植Key words
Acinetobacter baumannii/Infection/Multidrug resistance-associated proteins/Liver transplantation引用本文复制引用
刘剑戎,易慧敏,吕海金,安玉玲,易小猛,魏绪霞,熊亮,黎利娟,张英才,杨扬..鲍曼不动杆菌感染和耐药性分析[J].中华肝脏外科手术学电子杂志,2016,5(5):319-322,4.基金项目
国家自然科学基金（81300365，81370575，81570593）；十二五国家科技重大专项（2012ZX100020100010）；广东省自然科学基金（2015A030312013）；广东省科技计划项目（2014A020211010）；广州市科技计划健康医疗协同创新重大专项 （）
