北京大学学报（医学版）2016，Vol.48Issue(5)：830-834,5.DOI:10.3969/j.issn.1671-167X.2016.05.015
磁共振肌肉脂肪化色阶直方图评估法的临床应用
Clinical application of MRI histogram in evaluation of muscle fatty infiltration
摘要
Abstract
Objective:To describe a method based on analysis of the histogram of intensity values pro-duced from the magnetic resonance imaging (MRI)for quantifying the degree of fatty infiltration. Methods:The study included 25 patients with dystrophinopathy.All the subjects underwent muscle MRI test at thigh level.The histogram Mvalues of 250 muscles adjusted for subcutaneous fat,representing the degree of fatty infiltration,were compared with the expert visual reading using the modified Mercuri scale.Results:There was a significant positive correlation between the histogram Mvalues and the scores of visual reading (r =0.854,P <0.001).The distinct pattern of muscle involvement detected in the pa-tients with dystrophinopathy in our study of histogram M values was similar to that of visual reading and results in literature.The histogram M values had stronger correlations with the clinical data than the scores of visual reading as follows:the correlations with age (r =0.730,P <0.001 )and (r =0.753, P <0.001);with strength of knee extensor (r =-0.468,P =0.024)and (r =-0.460,P =0.027) respectively.Meanwhile,the histogram Mvalues analysis had better repeatability than visual reading with the interclass correlation coefficient was 0.998 (95% CI:0.997 -0.998,P <0.001)and 0.958 (95%CI:0.946 -0.967,P <0.001)respectively.Conclusion:Histogram Mvalues analysis of MRI with the advantages of repeatability and objectivity can be used to evaluate the degree of muscle fatty infiltration.关键词
磁共振成像/肌,骨骼/脂肪组织/肌肉脂肪化/直方图Key words
Magnetic resonance imaging/Muscle,skeletal/Adipose tissue/Muscle fatty infiltration/Histogram分类
医药卫生引用本文复制引用
郑艺明,杜婧,李文竹,王朝霞,张巍,肖江喜,袁云..磁共振肌肉脂肪化色阶直方图评估法的临床应用[J].北京大学学报（医学版）,2016,48(5):830-834,5.基金项目
“十二五”国家科技重大专项课题（2011ZX09307-001-07）和科技部国际合作课题（2010DFA31070）资助 Supported by the National Major Scientific and Technological Special Project for the 12th Five-Year Plan （2011ZX09307-001-07）and the International Cooperation Project of the Ministry of Science and Technology of the People’s Republic of China （）
