摘要
Abstract
Objective:To observe and explore the efficacy of Tanreqing injection in treatment of acute exacerbation of chronic obstructive pulmonary disease(AECOPD)based on conventional treatment and its effects on C-reactive protein(CRP),tumor necrosis factor-α(TNF-α),procalcitonin(PCT).Methods:123 AECOPD patients were divided into observation group (64 cases)and control group (59 cases),control group was given conventional treatment,observation group was combined with Tanreqing injection based on the control group,daily for 20mL per time,treatment for 10 to 14 d,after 2 weeks of treatment,pulmonary function was measured,blood samples were collected to determine the level of CRP,TNF-α,PCT,and the clinical efficacies of two groups were compared.Results:2 weeks after treatment,the FVC (2.68 ±0.5 1 )L、FEV 1 (1 .96 ±0.58)L、FEV 1 /FVC(70.8 ±7.1 )% of observation group were all higher than the control group(2.49 ±0.45)L,(1 .76 ±0.52)L,(67.5 ±6.7)% (P <0.05 ).The concentration of peripheral blood in observation group TNF-α(28.5 ±5.4)pg /mL,CRP(5.3 ±1 .6)mg /L,PCT(132.4 ±25.5 )pg /mL were significantly lower than those of the control group(36.2 ±7.1 )pg /mL,(8.1 ±2.5 )mg /L,(160.5 ±30.4)pg /mL(P <0.05 ).The observation group with invasive ventilation ratio (23.4%)was significantly lower than control group (42.4%)(χ2 =5.016,P =0.025 ).After treatment, clinical efficacy composition of 2 groups without significant difference (Z =-1 .397,P =0.163 ),the total efficiency (92.2%)was higher than control group (84.7%)(χ2 =1 .686,P =0.194).Conclusion:Based on conventional treatment,Tanreqing injection com-bined with treatment of AECOPD can significantly reduce systemic inflammatory response,improve lung function,and further improve the clinical efficacy.关键词
慢阻肺急性发作/痰热清注射液/肺功能/C反应蛋白/肿瘤坏死因子-α/降钙素原Key words
Acute exacerbation of chronic obstructive pulmonary disease/Tanreqing injection/Pulmonary /function/C-reactive protein/tumor necrosis factor-α/Procalcitonin分类
医药卫生
