川北医学院学报2016，Vol.31Issue(5)：745-748,4.DOI:10.3969/j.issn.1005-3697.2016.05.035
氨氯地平联合阿托伐他汀对老年急性缺血性卒中合并高血压患者的影响
Effect of amlodipine combined with different doses of atorvastatin on the regulation of blood lipids and neurological function in elderly patients with acute ischemic stroke complicated by hypertension
董素娟 1周军 2代晓杰1
作者信息
- 1. 西安高新医院神经内科，陕西 西安 710075
- 2. 商洛市中心医院神经内科，陕西 商洛 726000
- 折叠
摘要
Abstract
Objective:To explore the effect of amlodipine combined with different doses of atorvastatin on the regulation of blood lipids and neurological function in elderly patients with acute ischemic stroke complicated by hypertension.Methods:Eighty-three patients with acute ischemic stroke complicated by hypertension were randomly assigned into standard group (n =42 )and intensive group (n =41 ).Based on routine treatment,both groups were added Amlodipine Besylate Tablets.Additionally,standard group and in-tensive group were treated with Atorvastatin Calcium Tablets,20 mg and 40 mg per time respectively.The changes of blood pressure and lipid-related indexes before and 4 weeks after treatment as well as scores of National Institute of Health Stroke Scale (NIHSS),modified Rankin scale and Barthel index (BI)before and 12 weeks after treatment were all compared in two groups.The adverse reactions and recurrent conditions of cerebrovascular events were recorded in two groups in observation period.Results:Four weeks after treatment, both systolic blood pressure (SBP)and diastolic blood pressure (DBP)decreased significantly in two groups when compared with treatment before (P <0.01 ).When compared with treatment before,the levels of total cholesterol (TC),triglyceride (TG)and low density lipoprotein cholesterol (LDL-C)went down in two groups (P <0.01 ),in which the decreased range of TC and LDL-C was more significant in intensive group (P <0.05 or P <0.01 ).Twelve weeks after treatment,both NHISS and mRS scores in two groups reduced,while BI scores increased(P <0.05 or P <0.01 ).The improved degree of NHISS and mRS scores in intensive group was su-perior to that of standard group (P <0.05 or P <0.01 ).None of patients suffered from severe adverse reactions in two groups,and there was no statistical significance regarding the recurrence rate of cerebrovascular events (P >0.05 ).Conclusion:For elderly pa-tients with acute ischemic stroke complicated by hypertension,the intensive treatment of amlodipine combined with atorvastatin has bet-ter effects on regulation of blood lipids and improvement of neurological function when compared with routine treatment.关键词
缺血性卒中/高血压/阿托伐他汀/氨氯地平/血脂/神经功能Key words
Ischemic stroke/Hypertension/Atorvastatin/Amlodipine/Blood lipis/Neurological function分类
医药卫生引用本文复制引用
董素娟,周军,代晓杰..氨氯地平联合阿托伐他汀对老年急性缺血性卒中合并高血压患者的影响[J].川北医学院学报,2016,31(5):745-748,4.
