南方医科大学学报2016，Vol.36Issue(10)：1352-1356,5.DOI:10.3969/j.issn.1673-4254.2016.10.09
低剂量聚焦超声预辐照与微泡在高强度聚焦超声消融兔肝VX2移植瘤中的增效作用比较
Effect of low-dose focused ultrasound pre-irradiation versus microbubbles for enhancing high-intensity focused ultrasound ablation of VX2 hepatic tumor in rabbits
摘要
Abstract
Objective To compare the effect of low-dose focused ultrasound pre-irradiation and microbubbles for enhancing the ablation effect of high intensity focused ultrasound (HIFU) on VX2 hepatic tumor in rabbits. Methods Fifty-five rabbits bearing VX2 hepatic tumor were randomly divided into low-dose pre-irradiation+HIFU ablation group, microbubbles+HIFU ablation group, and HIFU ablation group for corresponding treatments. The pathological changes in the tumors after low-dose irradiation, time for HIFU ablation, tumor volume with coagulative necrosis, energy efficiency factor (EEF), pathological changes in the ablated tumor, and sound channel of HIFU ablation were observed. Results Tumor cell edema, vacuolar changes in the cytoplasm and tumor interstitial vascular congestion were observed 24 h after low-dose pre-irradiation. The ablation time were significantly shorter, coagulative necrosis volume was larger, and EEF was lower in low-dose irradiation+HIFU ablation group and microbubbles+HIFU ablation group than in simple HIFU ablation group (P<0.05), but the differences between the former two groups were not significant. The effectiveness and stability of the synergistic effect of low-dose pre-irradiation were inferior to microbubbles, but the former ensured a better safety of the sound channel. Conclusion Low-dose irradiation has comparable synergistic effect in HIFU with microbubbles with such advantages as non-invasiveness, high concentration and good safety, and can be a potentially new method to enhance the efficiency of HIFU.关键词
低剂量/聚焦超声/微泡/增效Key words
low dose/focused ultrasound/microbubbles/synergistic effect引用本文复制引用
张奕,杨超,邹建中,陈菲,欧霞,邹海蓉,王雁..低剂量聚焦超声预辐照与微泡在高强度聚焦超声消融兔肝VX2移植瘤中的增效作用比较[J].南方医科大学学报,2016,36(10):1352-1356,5.基金项目
国家自然科学基金重点项目（30830040）；国家临床重点专科建设项目（国卫医办函[2013]544号） Supported by National Natural Science Foundation of China (30830040) （30830040）
