南方医科大学学报2016，Vol.36Issue(10)：1364-1368,5.DOI:10.3969/j.issn.1673-4254.2016.10.11
MicroRNA-155在甲状腺乳头状癌中的表达及临床意义
Expression of microRNA-155 in papillary thyroid carcinoma and its clinical significance
摘要
Abstract
Objective To investigate the correlation of microRNA-155 (miR-155) expression with clinicopathological features of patients with papillary thyroid carcinoma (PTC) and explore the value of miR-155 in prognostic assessment of PTC. Methods We collected 86 pairs of fresh PTC and adjacent tissues to examine the expression of miR-155 using fluorescent quantitative PCR. miR-155 expressions in the tissues were analyzed in relation to the clinicopathological features of the patients. Results Compared with the paired adjacent tissues, 69.8%(60/86) of the PTC tissues showed up-regulated miR-155 expression by 2.63± 2.73 folds. Up-regulated miR-155 expressions were associated with a larger tumor size (1.66 ± 0.96 vs 1.19 ± 0.52 cm, P=0.021), a higher likeliness of extrathyroid invasion (56.7%vs 23.1%, P=0.004), a higher rate of lymph node metastasis (70%vs 46.2%, P=0.036), a more advanced TNM stage, and a higher rate of III-IV stage of the tumor (20%vs 0%, P=0.014). The expression level of miR-155 in PTC tissues was positively correlated with lymph node metastasis (r=0.531, P=0.001). Conclusion PTC patients with miR-155 over-expression tend to have a greater tumor size, a greater likeliness of extrathyroid involvement, a higher rate of cervical lymph node metastasis and a more advanced TNM stage. The high expression of miR-155 in the tumor may indicate a poor prognosis of PTC patients.关键词
甲状腺肿瘤/甲状腺乳头状癌/MicroRNA-155Key words
thyroid tumor/papillary thyroid carcinoma/microRNA-155引用本文复制引用
朱有志,陈祥锦,郑珂,张惠灏,陈玲,吴坤琳,任彩虹,王宗财,孔令君,阮炜鸿..MicroRNA-155在甲状腺乳头状癌中的表达及临床意义[J].南方医科大学学报,2016,36(10):1364-1368,5.基金项目
国家临床重点专科建设项目；福建省中青年教师教育科技项目（JA14146）；福建省卫生厅青年课题 （）
