南方医科大学学报2016，Vol.36Issue(10)：1382-1385,4.DOI:10.3969/j.issn.1673-4254.2016.10.14
肾病综合征患儿的血清游离脂肪酸与白蛋白比值显著升高
Serum non-esterified fatty acids to albumin ratio increased significantly in children with ne-phrotic syndrome
摘要
Abstract
Objective To analyze serum levels of non-esterified fatty acids (NEFA) and albumin (ALB) in children with nephrotic syndrome (NS) and investigate the clinical significance of altered serum NEFA to ALB ratio in children with NS in acute and remission phases. Methods Serum levels of NEFA and ALB were measured in 55 NS children in acute phase, in 33 NS children in remission and in 122 healthy control children, and the ratio of NEFA to ALB was calculated. The other lipid/lipoprotein and renal function parameters were also analyzed in these children. Results Compared with the healthy control children, children with NS had a significantly decreased serum ALB level (t=11.152, P<0.001) and a significantly increased NEFA to ALB ratio (t=4.991, P<0.001). Compared with NS children in remission, those in acute phase showed a significantly decreased ALB (Z=7.822, P<0.001) and an increased NEFA to ALB ratio (t=4.991, P<0.001). In all the NS children, NEFA to ALB ratio was positively correlated with the levels of TC (r=0.564, P<0.001), TG (r=0.444, P<0.001), LDL-C (r=0.625, P<0.001), urea (r=0.437, P<0.001), creatinine (r=0.278, P=0.013), and uric acid (r=0.397, P<0.001), while negatively correlated with the level of total protein (r=-0.461, P<0.001). Multiple linear regression analyses showed that NEFA to ALB ratio was independently associated with serum urea levels (β=0.703, P=0.001;adjusted R2=0.494) after adjustment of other related factors. Conclusion Serum NEFA to ALB ratio is significantly increased in NS children in close association with impaired kidney function, and may function as a novel parameter for assessing the development of NS.关键词
肾病综合征/游离脂肪酸/白蛋白/肾功能Key words
nephrotic syndrome/non-esterified fatty acids/albumin/kidney function引用本文复制引用
樊春荔,吴嘉,卜晓敏,万淑君,郭鹏涛,马艳娟,汪俊军..肾病综合征患儿的血清游离脂肪酸与白蛋白比值显著升高[J].南方医科大学学报,2016,36(10):1382-1385,4.基金项目
国家自然科学基金（81271904，81572074）；国家重大科学仪器设备开发专项（2012YQ03026109）；成都军区课题（C41007） Supported by National Natural Science Foundation of China (81271904，81572074) （81271904，81572074）
