南方医科大学学报2016，Vol.36Issue(10)：1386-1389,1400,5.DOI:10.3969/j.issn.1673-4254.2016.10.15
血清糖类抗原125在慢性阻塞性肺疾病急性加重期中的临床意义
Clinical significance of serum carbohydrate antigen 125 in acute exacerbation of chronic ob-structive pulmonary disease
摘要
Abstract
Objective To study the serum level of carbohydrate antigen 125 (CA125) in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and its relation with pulmonary hypertension. Methods Forty-six patients with AECOPD complicated by pulmonary hypertension, 46 with AECOPD and 38 healthy control subjects were examined for their clinical data, pulmonary function, echocardiographic findings, and serum levels of lung tumor markers and brain natriuretic peptide (BNP). Results Compared with the healthy control group, COPD patients with or without pulmonary hypertension showed significantly decreased pulmonary function (P<0.05), especially in those with AECOPD and concurrent pulmonary hypertension (P<0.05). Serum CA125 level was obviously higher in AECOPD group than in the healthy control group, and further increased in AECOPD patients with pulmonary hypertension (P<0.05). The levels of lung tumor markers (CEA, NSE, CYFRA and PROGRP) were similar among the 3 groups (P>0.05). The serum level of BNP in patients with AECOPD and concurrent pulmonary hypertension was significantly higher than that in patients with AECOPD (P<0.05). Pearson linear correlation analysis showed that serum CA125 was positively correlated with pulmonary artery systolic pressure and BNP in AECOPD patients with pulmonary hypertension (P<0.01). Conclusion Serum CA125 may serve as a serological index to identify AECOPD patients with pulmonary hypertension.关键词
慢性阻塞性肺疾病/肺动脉高压/急性加重期/糖类抗原125/脑钠肽Key words
chronic obstructive pulmonary disease/pulmonary hypertension/acute exacerbation/carbohydrate antigen 125/brain natriuretic peptide引用本文复制引用
张明,李雅莉,杨侠,单虎,张秋红,冯向莉,谢颖颖,唐晶晶,张洁..血清糖类抗原125在慢性阻塞性肺疾病急性加重期中的临床意义[J].南方医科大学学报,2016,36(10):1386-1389,1400,5.基金项目
陕西省自然科学基础研究计划（2016JQ8048）；中央高校基本科研业务费专项资金资助 （）
