南方医科大学学报2016，Vol.36Issue(10)：1390-1395,6.DOI:10.3969/j.issn.1673-4254.2016.10.16
ALDH1、CXCR4、E-cadherin在胃癌组织中的表达及与淋巴结转移的关系
Expression of ALDH1, CXCR4 and E-cadherin in castric carcinoma and their roles in lymphatic metastasis
摘要
Abstract
Objective To investigate the expression of ALDH1, CXCR4 and E-cadherin in gastric carcinoma and their roles in lymphatic metastasis. Methods Surgical specimens from 127 cases of gastric carcinoma were examined for expressions of ALDH1, CXCR4 and E-cadherin immuohistochemistry with 60 adjacent tissues as control. The associations of ALDH1, CXCR4 and E-cadherin with the clinicopathological pfeatures, 5-year survival rate and lymph node metastasis of the patients were analyzed. Results ALDH1, CXCR4 and E-cadherin were positive in 57.5%(73/127), 63.8%(81/127), and 36.2%(46/127) of the gastric carcinoma tissues, respectively, showing significant differences from the rates in the adjacent tissues (P<0.05). The expression of ALDH1 was significantly correlated with TNM stage and lymph node metastasis (P<0.05), CXCR4 was significantly correlated with the invasion depth, differentiation, TNM stage and lymph node metastasis of the tumor (P<0.05), and E-cadherin was significantly correlated with the invasion depth, differentiation and lymph node metastasis (P<0.05). The positivity rates of ALDH1, CXCR4 and E-cadherin were higher in cases with lymph node metastasis than in those without metastasis. E-cadherin expression was inversely correlated with ALDH1 and CXCR4 expression, and the latter two were positively correlated (P<0.001). Overexpressions of ALDH1 and CXCR4 and a decreased expression of E-cadherin were all related to a poor prognosis of the patients (P<0.05). The expressions ofALDH1, CXCR4 and E-cadherin were all independent prognostic factors of gastric carcinoma. Conclusion The expressions of ALDH1, CXCR4 and E-cadherin are associated with the invasion, metastasis and prognosis of gastric carcinoma, and their combined detection provides important evidence for predicting the progression and prognosis of gastric carcinoma.关键词
胃癌/ALDH1/CXCR4/E-cadherin/淋巴结转移Key words
gastric carcinoma/aldehyde dehydrogenase 1/CXCR4/E-cadherin/lymphatic metastasis引用本文复制引用
赵艳,金鑫,李楠,李靖,钱军..ALDH1、CXCR4、E-cadherin在胃癌组织中的表达及与淋巴结转移的关系[J].南方医科大学学报,2016,36(10):1390-1395,6.基金项目
国家自然科学基金（81173386）；安徽省高等学校自然科学研究一般项目（KJ2015B045by）；蚌埠医学院科研课题计划（BYKY1426ZD） Supported by National Natural Science Foundation of China (81173386) （81173386）
