南方医科大学学报2016，Vol.36Issue(10)：1396-1400,5.DOI:10.3969/j.issn.1673-4254.2016.10.17
顺式阿曲库铵按去脂肪体质量诱导麻醉对病态肥胖患者药代动力学的影响
Pharmacokinetics of a cisatracurium dose according to fat-free mass for anesthesia induction in morbidly obese patients
摘要
Abstract
Objective To compare the pharmacokinetics of cisatracurium between normal weight patients and morbidly obese patients. Methods Twelve obese ASA I-II patients (BMI≥35 kg/m2) undergoing laparoscopic Roux-en-Y gastric bypass and 12 normal weight ASA I-II patients (BMI of 18.5-24 kg/m2) undergoing laparoscopic surgery were enrolled. The obese patients were given a cisatracurium dose of 0.15 mg/kg according to the fat-free mass (FFM), and the non-obese patients received a dose of 0.15 mg/kg according to the total body weight. Plasma concentrations of cisatracurium was monitored in the patients with high-performance liquid chromatography (HPLC) before anesthetic induction and at 1, 2, 4, 6, 8, 10, 12, 15, and 20 min after cisatracurium administration and the pharmacokinetic parameters were computed. SBP, DBP, HR, MAP, SpO2 and PetCO2 were recorded before anesthetic induction (T0) and at 1 min (T1), 2 min (T2), 4 min (T3) after cisatracurium administration. Results Compared with those measured at T0, SBP, DBP and MAP in the 2 groups were significantly decreased at the time points of T1-3 (P<0.05). Compared with the non-obese patients, the obese patients showed significantly increased Hct level (P<0.05). The total clearance, apparent volume of distribution, and distribution and elimination half-life of the drug were similar between the 2 groups (P>0.05). The plasma concentration of cisatracurium at T1- 2 was significantly decreased in the obese patients compared with that in the non-obese patients (P<0.05). Conclusion Cisatracurium doses according to fat-free mass is clinically reasonable for inducing anesthesia in morbidly obese patients, but due to a prolonged muscle relax onset time, the timing of tracheal intubation should be delayed by 1-2 min.关键词
顺式阿曲库铵/病态肥胖患者/药代动力学/去脂肪体质量Key words
cisatracurium/morbidly obese patients/pharmacokinetics/fat free mass引用本文复制引用
李佳阳,邹启荣,彭雪梅..顺式阿曲库铵按去脂肪体质量诱导麻醉对病态肥胖患者药代动力学的影响[J].南方医科大学学报,2016,36(10):1396-1400,5.基金项目
中央高校基本科研业务费专项资金资助 （）
