摘要
Abstract
Objective To explore the application and significance of testing high-risk human papilloma virus (HR-HPV) in the following of patients with cervical intraepithelial neoplasia (CIN) after loop electrosurgieal excision procedure (LEEP).Methods 216 patients with CIN Ⅱ or CIN Ⅲ underwent LEEP in our hospital from Jan.2009 to Dec.2013 were followed up for 2 years.HR-HPV was detected by hybrid capture (HC2) and thinprep cytologic test (TCT) was performed.HPV clearance,the remain of cervical lesion,and the relapse rate were recorded,and the significance of HPV and TCT in monitoring remain and relapse were compared.Results 17 cases (7.9％) had positive surgical margin after the operation,and 31 cases (14.4％) showed remain or relapse after 24 months' follow-up.The negative rate of HR-HPV significantly increased at the 6th month after operation,with statistically significant difference compared with that at the 3rd month.54 cases had positive HR-HPV at the 6th month after operation,31 cases (57.4％) of whom showed remain or relapse,there was no remain or relapse in HR-HPV negative patients.The sensitivity,specificity,positive predictive value,and negative predictive value of HR-HPV in diagnosing remain or relapse at the 6th month after LEEP were 100％,88.9％,57.4％,and 100％ respectively,while those of TCT were 75.6％,91.1％,53.8％,and 94.4％ respectively,those of HR-HPV were superior to those of TCT.Conclusion HR-HPV is a sensitive marker for early monitoring postoperative remain or relapse after CIN surgery.More attention should be paid to postoperative patients with continuously positive HPV over 6 months.关键词
高危型人乳头瘤病毒/宫颈上皮内瘤变/宫颈环形电切术/病变残留或复发Key words
High-risk human papilloma virus/Cervical intraepithelial neoplasia/Loop electrosurgical excision procedure/Remain or relapse
