摘要
Abstract
Objective To study the serum levels of PSA,PAP joint detection in the diagnosis of prostate cancer and the effect of estrogen.Methods 60 patients with prostate cancer were selected in department of urology of our hospital were given oral diethylstilbestrol 3 mg,once a day,and oral aspirin enteric-coated sustained release tablets 100 mg,once a day,for 2 consecutive months.At the same time,we selected 60 cases of benign prostatic hyperplasia,60 healthy subjects at the same period as normal control group.Detected serum PSA,PAP levels in prostatic hyperplasia group,normal control group,prostate cancer group before and after treatment with radioimmunoassay.Observed IPSS score in prostate cancer group before and after treatment.Results ① Serum PSA,PAP levels in prostate cancer group were (80.64±64.72)ng/ml,(45.86±55.73)ng/ml,significantly higher than (5.82±5.96)ng/ml,(1.35±0.92)ng/ml in prostatic hyperplasia group and (0.75±0.24)ng/ml,(0.79±0.61) ng/ml in normal control group,with statistically significant differences (P＜0.05);there were no statistically significant differences between prostatic hyperplasia group and normal control group (P＞0.05).② The positive detection rate and the detection sensitivity of PSA for prostate cancer was 78.33％,the specificity was 70％,the positive detection rate and the detection sensitivity of PAP for prostate cancer was 53.33％,the specificity was 93.33％;the positive detection rate and the detection sensitivity of PSA for prostate cancer was significantly higher than that of PAP,the specificity was lower,with statistically significant differences (P＜0.05).③ Serum PSA,PAP levels in prostate cancer group after treatment were (9.71±10.38)ng/ml,(7.82±11.77)ng/ml,decreased significantly compared with those before treatment,with statistically significant differences (P＜0.05).④ Prostate symptoms of prostate cancer group improved after treatment,IPSS score decreased significantly [(21.66±4.61) before treatment vs.(7.68±1.12) after treatment],with statistically significant difference (P＜0.05).Conclusions Combined detection of serum PSA,PAP in the diagnosis of prostate cancer can improve the sensitivity and specificity,and can be used for early diagnosis of prostate cancer;estrogen can lower their levels,improve the symptoms of prostate cancer,inhibit the progress of the disease.关键词
前列腺癌/前列腺特异性抗原/前列腺酸性磷酸酶/雌激素Key words
Prostate cancer/Prostate specific antigen/Prostatic acid phosphatase/Estrogen
