国际医药卫生导报2016，Vol.22Issue(20)：3074-3076,3.DOI:10.3760/cma.j.issn.1007-1245.2016.20.005
延长双重抗血小板治疗对心肌梗死后高危稳定性冠心病患者预后的影响
Effect of prolonged dual antiplatelet therapy on prognosis of high risk patients with stable coronary heart disease after myocardial infarction
杨帆 1李平 2张文才 1张真真 1王丽 1赵洛沙1
作者信息
- 1. 450052 郑州大学第一附属医院心内科
- 2. 451191 郑州,河南医学高等专科学校医学系
- 折叠
摘要
Abstract
Objective To exolore the effect of prolonged dual antiplatelet therapy on the prognosis of high risk patients with stable coronary heart disease after myocardial infarction.Methods 84 high risk patients with stable coronary heart disease after myocardial infarction treated at our hospital from June,2013 to August,2014 were selected as study objects and were randomly divided into a control group and an observation group,42 for each group.The control group were treated with dual antiplatelet therapy for 12 months and the observation group for 24 months.At the end of the treatment,the rate of blood lipid returning to normal,the normal rate of left ventricular ejection fraction,the platelet aggregation rate,and curative effect were compared between these two groups.The incidences of multiple terminal events (cardiovascular death,myocardial infarction,stroke) and gastrointestinal hemorrhage in these two groups were recorded.Results The rate of blood lipid returning to normal,the normal rate of left ventricular ejection fraction,and the platelet aggregation rate were 90.5％,88.1％,and 4.8％ in the observation group and 71.4％,69.0％,and 23.8％ in the control group (P ＜ 0.05).The incidences of multiple terminal events (cardiovascular death,myocardial infarction,stroke) and gastrointestinal hemorrhage were 21.4％ and 19.0％ in the observation group and were 7.1％ and 14.3％ in the control group (P ＞ 0.05).Conclusions Long-term dual antiplatelet therapy for high risk patients with stable coronary heart disease after myocardial infarction is effective and can effectively improve blood lipid level,left ventricular ejection fraction,and platelet aggregation;and there is no statistical differences in the incidences of gastrointestinal hemorrhage and multiple terminal events between long-term and short-term dual antiplatelet therapy.Therefore,it is worth for clinical application.关键词
双重抗血小板治疗/心肌梗死/稳定性冠心病/预后Key words
Dual antiplatelet therapy/Myocardial infarction/Stable coronary heart disease/Prognosis引用本文复制引用
杨帆,李平,张文才,张真真,王丽,赵洛沙..延长双重抗血小板治疗对心肌梗死后高危稳定性冠心病患者预后的影响[J].国际医药卫生导报,2016,22(20):3074-3076,3.
