摘要
Abstract
Objective To study the effect of early using nicardipine for improving cerebral blood flow and preventing CVS in patients with subarachnoid hemorrhage.Methods 70 patients with subarachnoid hemorrhage treated at our hospital from January to October,2015 were selected as study objects and were divided into an observation group and a control group by random lot method,35 cases for each group.The control group received conventional sedation,analgesia,control of intracranial pressure,and prevention of rebleeding;the intracranial pressure and cerebral blood flow were detected before the treatment.In addition,the observation group were treated with nicardipine.The changes of cerebral blood flow and intracranial pressure in the two groups were compared when admitted and 7,14,and 21 days after the treatment.The occurrence of CVS and prognosis were observed.Results There were no statistical differences in intracranial pressure and cerebral blood flow between these two groups when admitted (P ＞ 0.05).7,14,and 21 days after the treatment,the intracranial pressure was (19.42±3.42) mmHg (1 mmHg=0.133 kPa),(13.05±1.86) mmHg,and (11.74±2.54) mmHg and cerebral blood flow velocity (104.25±20.41) cm/s,(101.55±10.25)cm/s,and (94.81±9.6) crn/s in the observation group,respectively and was (27.42±5.01) mmHg,(16.75±1.67) mmHg,and (20.60±1.85) mmHg and (134.24±28.66) cm/s,(117.25±25.41) cm/s,and (113.66±8.68) crn/s in the control group,respectively (P ＜ 0.05).The incidence of CVS and the proportion of the patients with severe disability were 2.86％ and 8.57％ in the observation group and were 17.14％ and 28.57％ in the control group (P ＜ 0.05).There were no statistical differences in the good rate and moderate disability rate between these two groups (P ＞ 0.05).Conclusions Nicardipine has remarkable efficacy in the treatment of subarachnoid hemorrhage and can significantly improve the patients' cerebral blood flow,intracranial pressure,and prognosis and remarkably prevent CVS,so its clinical application value is high.关键词
尼卡地平/蛛网膜下腔出血/脑血流/CVSKey words
Nicardipine/Subarachnoid hemorrhage/Cerebral blood flow/CVS
