国际妇产科学杂志2016，Vol.43Issue(5)：502-505,4.
微小RNA在卵巢上皮性肿瘤中诊断及治疗的研究进展
Progress in the Diagnosis and Treatment of miRNAs in Epithelial Ovarian Tumors
摘要
Abstract
Epithelial ovarian tumor (EOC) is the most lethal gynecologic malignancy, and it is the fifth leading cause of cancer deaths in women. In order to improve survival in women with advanced EOC, it is important to overcome the drug resistance. miRNAs can act on multiple genes associated with a chemoresistant phenotype, which have been the promising tools in this regard. miRNAs deregulation has been identified as an important feature in EOC. Combination of miR-205 and let-7f expression in plasma samples of EOC patients provided high diagnostic accuracy for stage Ⅰdisease in EOC;miR-484, miR-642, miR-217 and miR-181a can predict resistance, miR-509-3p, miR-145, miR-181a miR-34 can inhibit proliferation of platinum resistant cell lines;miR-34c is the only markers as predictor of relapse, miR-519 is related with low survival rate. The function of miRNAs as prognostic and therapeutic tools in EOC was summarized here.关键词
肿瘤标记,生物学/抗药性,肿瘤/卵巢肿瘤/微RNAsKey words
Tumor markers,biological/Drug resistance,neoplasm/Ovarian neoplasms/MicroRNAs引用本文复制引用
徐菲,钱莉莉,吴大保,周颖..微小RNA在卵巢上皮性肿瘤中诊断及治疗的研究进展[J].国际妇产科学杂志,2016,43(5):502-505,4.基金项目
国家自然科学基金（81001168，81272881），安徽省自然科学基金（1308085MH122），安徽省科技厅年度重点科研项目 （）
