国际妇产科学杂志2016，Vol.43Issue(5)：510-514,5.
伏隔核因子1在卵巢癌化疗耐药中的研究进展
Research Progress of Nucleus Accumbens 1 in Ovarian Cancer Chemoresistance
郑一頔 1汤小晗 1卢美松1
作者信息
- 1. 150001 哈尔滨医科大学附属第一医院妇产科
- 折叠
摘要
Abstract
Resistance to antineoplastic drugs is a major cause that leads to poor treatment effect in ovarian cancer. Finding effective ways of ovarian cancer chemoresistance reversal has become a hotspot at home and abroad. A rapidly growing number of recent studies shows that, overexpression of nucleus accumbens 1 (NAC-1) in ovarian cancer is not only involved in pathogenesis, progression, metastasis and recurrence, but also closely related with tumor resistance. NAC-1 regulates multiple signal pathways of ovarian cancer chemoresistance to reduce anti-tumor drugs sensitivity. Therefore, the specific targeting of NAC-1 could open new avenues for reversing ovarian cancer chemoresistance, the specific inhibition of NAC-1 activity in ovarian cancer cells combined with chemotherapy is expected to be an effective cancer treatment strategy. This article reviews the mechanism of NAC-1 in ovarian cancer chemoresistance.关键词
伏隔核因子1/伏核/卵巢肿瘤/药物疗法/抗药性,肿瘤/药物耐受性/信号传导Key words
Nucleus accumbens 1/Nucleus accumbens/Ovarian neoplasms/Drug therapy/Drug resistance, neoplasm/Drug tolerance/Signal transduction引用本文复制引用
郑一頔,汤小晗,卢美松..伏隔核因子1在卵巢癌化疗耐药中的研究进展[J].国际妇产科学杂志,2016,43(5):510-514,5.
