国际妇产科学杂志2016，Vol.43Issue(5)：519-523,5.
血管内皮生长因子A在宫颈癌发病机制中的研究进展
Research Progress of Vascular Endothelial Growth Factor-A in the Pathogenesis of Cervical Cancer
摘要
Abstract
Vascular endothelial growth factor-A (VEGF-A) is a specific regulator of angiogenesis. In the transition from cervical lesions to cervical cancer, VEGF-A provides tumor cells with nutrients and transfer pathways by inducing angiogenesis. A variety of molecules that play a crucial role in VEGF-A activated angiogenesis signaling pathways participate in the development of cervical cancer. E6, E7 proteins and immune Toll-like receptors induced by HPV infection and peroxisome proliferator-activated receptors (PPARs) that have been reported to regulate the cellular fatty acid metabolism participate in the regulation of VEGF-A upstream signaling pathway. A variety of micoRNAs are also involved in the regulation of VEGF-A post-transcription and downstream signaling pathways, then induces angiogenesis in cervical cancer by promoting endothelial cell proliferation, survival, migration, and increasing vascular permeability. In addition, VEGF-A also can activate the DLL/Notch signaling pathway, which plays a key role in the process of endothelial cell differentiation. This article will do a review in the structure and function of VEGF-A and its related signal pathways in the pathogenesis of cervical carcinoma and targeted therapy, which may provide new ideas for analysing the pathogenesis of cervical cancer and searching for its therapeutic targets.关键词
血管内皮生长因子A/宫颈肿瘤/肿瘤治疗方案/血管生成抑制剂Key words
Vascular endothelial growth factor A/Uterine cervical neoplasms/Antineoplastic protocols/Angiogenesis inhibitors引用本文复制引用
王广娇,杨欣,郝敏..血管内皮生长因子A在宫颈癌发病机制中的研究进展[J].国际妇产科学杂志,2016,43(5):519-523,5.基金项目
国家卫生和计划生育委员会2014年度公益性卫生行业科研专项项目 （）
