吉首大学学报（自然科学版）2016，Vol.37Issue(5)：37-41,5.DOI:10.3969/j.cnki.jdxb.2016.05.009
铜催化N 芳基丙烯酰胺与丙酮成环合成吲哚酮
Copper-Catalyzed Cyclization Reaction of N-Aryl Acrylamide and Acetone to Synthetize Indolone
摘要
Abstract
A highly efficient and simple synthesis way of copper-catalyzed carbonylation and cyclization in active olefins to indole ketone was developed.At 100 ℃,the free radical tandem cyclization reaction with N-aryl acrylamides compounds synthesized a series of indole derivatives efficiently with cuprous chloride as a catalyst,di-tert-butyl peroxide (DTBP)as an oxidant and acetone as a solvent and reactant.We also explored the effects of different temperatures,catalysts,solvent and other factors on the reaction.Moreo-ver,the mechanism of the cyclization reaction was derived.关键词
铜催化/脱氢偶联环化/二叔丁基过氧化物/含丙酮基吲哚酮Key words
copper catalysis/cyclization dehydrogenation coupling/di-tert-butyl peroxide/acetonylindolin-one分类
化学化工引用本文复制引用
邓佑林,杨友,李立洋,王良能,李增增,付美玲,唐石..铜催化N 芳基丙烯酰胺与丙酮成环合成吲哚酮[J].吉首大学学报（自然科学版）,2016,37(5):37-41,5.基金项目
国家自然基金资助项目（21462017）；吉首大学研究生科研创新项目资助（JGY201636）；武陵山区特色植物资源开发与应用湖南省研究生培养创新基地开放项目资助（2014KFXM06）；吉首大学化学化工学院研究生专项科研课题 （）
