检验医学与临床2016，Vol.13Issue(20)：2876-2881,6.DOI:10.3969/j.issn.1672-9455.2016.20.013
中国丙型肝炎病毒基因型分布回顾及M eta分析
Prevalence of hepatitis C virus genotypes in China patients:a systematic review and Meta-analysis
摘要
Abstract
Objective To study the distribution characteristics of hepatitis C virus(HCV) genotypes in mainland area of China . Methods Original studies about HCV genotypes were retrieved in VIP ,CNKI ,WanFang Data and PubMed database .Unqualified objects were removed ,according to the exclusion standard .Stata software was used to make Meta‐analysis of the composition per‐centage .Results A total of 40 literatures were enrolled .Meta‐analysis of composition percentage on the genotypes was with P value less than 0 .1 ,indicating that combined analysis was infeasible .Between different geographical areas ,distribution characteristics of HCV genotypes of similar type of patient were obviously distinctive .HCV genotypes distribution of patients of various types from the same geographical area was also obviously distinctive .The dominant HCV subtype in mainland area of China was 1b ,yet 6a has surpassed 2a and became the second popular subtype .The percentages of 3b and 3a were increased ,and the percentages of other subtypes were also increased obviously .Conclusion Distribution of HCV subtypes in mainland area of China could be with a diver‐sified tendency ,thus the time and geographical factors should be considered to adopt prevention policies .关键词
中国/丙型肝炎病毒/基因型/测序/M eta分析Key words
China/hepatitis C virus/genotypes/sequencing/Meta-analysis引用本文复制引用
聂滨,张开炯,刘靳波,郭永灿,涂植光..中国丙型肝炎病毒基因型分布回顾及M eta分析[J].检验医学与临床,2016,13(20):2876-2881,6.基金项目
四川省宜宾市科技局医学科研项目（2015SF027）。 （）
