中南医学科学杂志2016，Vol.44Issue(5)：510-514,522,6.DOI:10.15972/j.cnki.43-1509/r.2016.05.007
新化合物ZM对大鼠血压的影响和对肠系膜上动脉的舒张作用
Effects of a New Compound ZM on Blood Pressure and Mesenteric Artery in Rats
张丽心 1周凯2
作者信息
- 1. 西安交通大学医学院附属红会医院临床药学科，陕西 西安710054
- 2. 西安交通大学第二附属医院药剂科
- 折叠
摘要
Abstract
Objective The aim of this study was to assess the effects of a new synthetic dihydropyridines compound ( ZM) on rat blood pressure and vasodilation of superior mesenteric artery and its mechanism. Method Spontaneously hypertensive rats were divided into the vehicle group,administration group (ZM 0.2 mg/kg,ZM 0.4 mg/kg).The blood pressure of rats was measured using a non￣invasive tail cuff blood pressure system in vivo before administration and 1 h after gavage.32 SD( Sprague￣Dawley) rats were used in vitro,Isometric tension of artery ring segments was recorded by myography system in vitro for the estimation of the effects of ZM on the vasoconstriction dose￣response curves of KCl,CaCl2 ,phenyleph￣rine and U46619.Effects of ZM on the contraction of artery ring segments in calcium￣free Krebs solution with phenylephrine, CaCl2 and caffine added were also evaluated. Results ZM (0.2 mg/kg) decreased the systolic and diastolic blood pres￣sure of spontaneously hypertensive rats 1h after gavage by 16% and 17%.ZM (0.4 mg/kg) decreased by 24% and 25% re￣spectively.There was no obvious difference of the vasorelaxation between intact and denuced endothelium mesenteric arterial ring segments in ZM(10-9~10-4 mol/L).ZM(3×10-8 mol/L,3×10-7 mol/L)shifted the concentration￣contratile curves in￣duced by KCl,CaCl2,phenylephrine and U46619 towards the right in a non￣parallel manner with the decreased Emax.ZM(3× 10-8 mol/L,3×10-7 mol/L,3×10-6 mol/L)obviously inhibited the contraction induced by CaCl2,but did not inhibit the con￣traction induced by phenylephrine and caffine in calcium￣free Krebs solution. Conclusion ZM can lower blood pressure of rats in vivo and concentration￣dependently relax the mesenteric artery in vitro. The mechanism of the effects of ZM was mainly through inhibiting extracellar calcium of artery muscle.关键词
ZM/大鼠/血压/肠系膜动脉/舒张Key words
ZM/rat/blood pressure/mesenteric artery/vasodilation分类
医药卫生引用本文复制引用
张丽心,周凯..新化合物ZM对大鼠血压的影响和对肠系膜上动脉的舒张作用[J].中南医学科学杂志,2016,44(5):510-514,522,6.
