护理研究2016，Vol.30Issue(31)：3872-3877,6.DOI:10.3969/j.issn.1009-6493.2016.31.009
短期大剂量阿托伐他汀预防冠状动脉造影后造影剂肾病的Meta分析
A Meta analysis of short term high dose atorvastatin to prevent contrast induced nephropathy after coronary angiography
摘要
Abstract
Objective:To investigate the effect of perioperative short term high dose atorvastatin to prevent contrast induced nephropathy (CIN)after coronary angiography.Methods:The keywords were used such as“atorvastatin/statins/statin”,“contrast induced nephropathy,CIN,nephrotoxicity,kidney failure”,and “con-trast,contrast medium”to search NGC,the Cochrane Library,the Joanna Briggs Institute Library(JBI),Em-base,MEDLINE,CBM,VIP,CNKI,and the Wanfang database to retrieve randomized controlled trials(RCTs). Two reviewers evaluated the quality of all RCTs and extracted their data;RevMan 5.0 was used for the meta analysis.Results:A total of 2 509 patients across 12 RCTs were included in this study.The patients in atorvasta-tin group were administered 40 mg or 80 mg of atorvastatin once before surgery.The Meta analysis showed that after surgery,the incidence of CIN(P <0.000 01)and the case number of patients who required hemodialy-sis(P =0.03),serum creatinine(P <0.000 01),and serum cystatin C(P <0.000 01)were significantly lower in atorvastatin group than these in control group.Conclusion:Short term high dose atorvastatin could reduce the incidence of CIN and the risk of hemodialysis after coronary angiography.关键词
冠状动脉造影/他汀类药物/阿托伐他汀/造影剂肾病/血液透析/血肌酐/血清胱抑素C/Meta分析Key words
coronary angiography/statins/atorvastatin/contrast induced nephropathy分类
医药卫生引用本文复制引用
黄艳秋,赵慧华..短期大剂量阿托伐他汀预防冠状动脉造影后造影剂肾病的Meta分析[J].护理研究,2016,30(31):3872-3877,6.基金项目
复旦大学护理科研基金立项项目,编号:FNF201408。 （）
