现代检验医学杂志2016，Vol.31Issue(5)：73-75,3.DOI:10.3969/j.issn.1671-7414.2016.05.019
超氧化物歧化酶及其同工酶和超敏C-反应蛋白与冠心病的关系
Relationship of Superoxide Dismutase Isoenzyme and High Sensitive C-Reactive Protein with Coronary Heart Disease
摘要
Abstract
Objective To investigate the relationship between the activity of superoxide dismutase (T-SOD)as well as its manganese superoxide dismutase isozyme (Mn-SOD),concentration levels of hypersensitive c-reactive protein(hs-CRP)and coronary heart disease.Methods The levels of serum T-SOD,Mn-SOD and hs-CRP were measured in 81 patients with coro-nary heart disease and 60 healthy controls,respectively.T-SOD was measured by colorimetricmethod and hs-CRP was meas-ured by latex enhanced immune turbidimetric assay.Results Compered with the control group,activity of T-SOD,Mn-SOD in CHD group were significantly decreased (t=9.41,6.34,all P<0.01).However,hs-CRP in CHD group were significantly increased to those in controls (t=3.09,P<0.05).The activity of T-SOD,Mn-SOD were negatively correlated with hs-CRP (P<0.01).Conclusion The variation of T-SOD,Mn-SOD activity and hs-CRP content were closely related to the occur-rence and development of CHD,they could be the impor tant indicators for riskfactors assessment of CHD.Moreover,con-joint analysis the correlation of T-SOD,Mn-SOD and hs-CRP has certain guiding significance for the clinical treatment and prognosis of coronary heart disease.关键词
冠心病/超敏C-反应蛋白/氧化物歧化酶/锰超氧化物歧化酶Key words
coronary heart disease/hs-CRP/T-SOD/Mn-SOD分类
医药卫生引用本文复制引用
姚创利,黎阳,鲁旭娟,姜小建..超氧化物歧化酶及其同工酶和超敏C-反应蛋白与冠心病的关系[J].现代检验医学杂志,2016,31(5):73-75,3.基金项目
陕西省科学技术研究发展计划项目（项目编号2013K12-02-10）。 （）
